Comparative diagnostic performance of contrast enhanced dual-energy spectral mammography, digital mammography and (99m) Tc MIBI scintimammography in detecting multicentric breast cancer

Congress:

ECR 2020

Poster Number:

C-00370

Type:

Scientific Exhibit

Keywords:

Breast, Oncology, Mammography, Nuclear medicine conventional, Diagnostic procedure, Cancer, Prospective, Diagnostic or prognostic study, Performed at one institution

Authors:

A. Chernaia¹, A. Mishchenko², S. N. Novikov³, P. Krivorotko³, P. Krzhivitskiy³, R. Ulyanova⁴, V. Danilov⁴; ¹Saint-Peterburg/RU, ²St. Petersburg/RU, ³St Petersburg/RU, ⁴Saint-Petersburg/RU

DOI:

10.26044/ecr2020/C-00370

DOI-Link:

https://dx.doi.org/10.26044/ecr2020/C-00370

Fig. 1: 60-year-old patient with complaints of a lump in the right breast. MMG: only...

Fig. 2: Scintimammogram of the same patient from Fig.1. in lateral projection with...

Fig. 6: Comparative analysis of contrast enhanced spectral mammography (CESM),...

Fig. 5: Comparative analysis of the diagnostic performance of digital mammography...

Purpose

To evaluate the diagnostic performance of digital mammography (MMG), contrast spectral dual-energy mammography (CESM) and (99m) Tc MIBI scintimammography in detecting multicentric breast cancer.

Methods and materials

437 women were examined at N. N. Petrov National Medical Research Center of Oncology; the mean age of the women was 50 years. Mammographic digital images were obtained on Senographe DS «GE» unit with a flat panel detector (Se, 100 μm) and image size - 24х31 cm² = 7.4 megapixel. Mammographic examination was performed with breast compression and included routine craniocaudal (CC) and mediolateral oblique (MLO) views of the breasts. An IV injection of 1.5 mL/kg body weight of a non-ionic contrast medium (Iohexol 350)...

Results

367 patients were diagnosed with breast cancer. 320 (87%) had unifocal lesions and 47 (13%) had multicentric lesions. CESM was performed in 112 women, 35 of them with multicentric breast cancer. Sensitivity, specificity and accuracy in the diagnosis of the multicentric breast cancer were 70.6%, 73.1%, 72.3% for digital mammography and 83%, 98%, 96% for scintimammography, respectively (Fig. 5.). Diagnostic performance of CESM in detecting multicentric breast cancer was significantly higher in comparison with digital mammography, with sensitivity of 93.9% (p = 0.02), specificity of...

Conclusion

CESM and (99m) Tc MIBI scintimammography showed high sensitivity, specificity and accuracy rates in multicentric breast cancer detection, as was evidenced by a high percentage of coincidence of pathological and radiological findings. The use of CESM and (99m) Tc MIBI scintimammography can significantly increase detection rate of multicentric breast cancer in comparison with digital mammography, primarily in women with high breast density.

Personal information and conflict of interest

A. Chernaya; Saint-Petersburg/RU - nothing to disclose A. Mishchenko; Saint-Petersburg/RU - nothing to disclose S. Novikov; Saint-Petersburg/RU - nothing to disclose P. Krzhivitskiy; Saint-Petersburg/RU - nothing to disclose P. Krivorotko; Saint-Petersburg/RU - nothing to disclose R. Ulyanova; Saint-Petersburg/RU - nothing to disclose V. Danilov; Saint-Petersburg/RU - nothing to disclose

References

Chernaya A.V., Kanaev S.V., Novikov S.N., Krzhivitsky P.I., Krivorotko P.V., Artemieva A.S., Popova N.S., Busko E.A., Shumakova T.A., Bashlyk V.O. Mammography and mammoscintigraphy with 99mTc-MIBI in the diagnosis of multicentric breast cancer. Vopr Onkol. 2017;63(6):876-881 Chernaya A.V., Novikov S.N., Krivorotko P.V., Ulyanova R.Kh., Danilov V.V. New technologies in breast cancer detection – contrast enhanced dual-energy spectral mammography. Medical Visualization. 2019; 23 (2): 49–61. DOI: 10.24835/1607-0763-2019-2-49-61. Ong E. Preoperative imaging for breast conservation surgery-do we need more than conventional imaging for local disease assessment. Gland Surg.2018...