To evaluate whether the peritumor/tumor apparent diffusion coefficient (ADC) ratio is associated with traditional histopathological biomarkers and published prognostic indexes, such as Nottingham Prognostic Index (NPI) and the predicted mortality calculated with PREDICT, in patients with invasive breast cancer.
Methods and materials
This study included 88 lesions (five bilateral) in 83 patients with primary invasive breast cancer in 2011 - 2014. The study was approved by the Research Ethics Board of our tertiary hospital and all clinical investigations were conducted according to the relevant guidelines and the principles expressed in the Declaration of Helsinki.
3.0-T MRI examinations were performed in the prone position (Philips Achieva 3.0 T TX, The Netherlands). The structural breast MRI protocol consisted of five sequences (Table 1). Diffusion-weighted imaging (DWI)...
Eighty-three women (mean age 57.5 ± 11.2 years, range 28–81 years) with 88 invasive (five bilateral) breast cancers were analyzed. Their patient profiles and tumor characteristics are described in Table 2 .
The associations of the peritumor/tumor ADC ratios with the histopathological parameters are presented in Table 3 .
The peritumor/tumor ADC ratio was significantly associated with tumor size (p < 0.001), histological grade (p = 0.005), Ki-67 index (p = 0.006), axillary LNM (p = 0.001), and LVI (p = 0.006), but was not...
Associations with histopathological factors
Tumors with larger diameters, higher histological grades, and more metastatic lymph nodes are known to be associated with peritumoral edema , which would cause higher peritumoral ADC values and result in higher peritumor/tumor ADC ratios. Indeed, in this study, we found that breast cancers with larger diameters, higher histological grades, and LNM were significantly associated with higher peritumor/tumor ADC ratios.
Ki-67 reflects the proliferation rate of various malignant tumors and is a prognostic or predictive factor in breast cancer. Higher Ki-67...
Personal information and conflict of interest
H. Okuma; Kuopio/FI - nothing to disclose M. Sudah; Kuopio/FI - nothing to disclose A. Niukkanen; Kuopio/FI - nothing to disclose A. Sutela; KYS, KUOPIO/FI - nothing to disclose A. N. J. Masarwah; Kuopio/FI - nothing to disclose P. Auvinen; Kuopio/FI - nothing to disclose A. Mannermaa; Kuopio/FI - nothing to disclose R. Vanninen; Kuopio/FI - nothing to disclose
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