Purpose
The early detection of the second ipsilateral or contralateral in-breast breast cancer recurrence is critical during follow upfor women treated by conservative breast surgery (CBS).
It has been well established that routine screening by mammogram is the standard modalityfor screening women; including women with personal history of breast cancer (PHBC) [1].
In patients with CBS, higher rate of interval cancers are reported, thus the radiologist job is to be alert for the significant changes in the images in comparison to prior surveillance series despite the...
Methods and materials
Methods
This is an observational retrospective study analyzing the outcome of all women treated with conservative breast therapy and attended for their post-conservative follow-up/screening mammography as a part of an IRB-approved screening protocol at the breast imaging unit,Women and Fetal Imaging (WAFI) clinic, in Cairo, Egypt.
These women had at least 2 follow up mammography visits registered at the clinic during the years of 2007– 2017.
Women with no follow-up registered after their initial diagnoses, or only one short term follow up visit with negative...
Results
The study included 300 women with median age of 50.7 years at diagnosis (range 21 -78 years). Fifty percent (150 women) were below the age of 50 at time of first diagnosis.
Out of the 300, 33 patients (10.9%) had a mammography detected breast cancer recurrence after a median follow up duration of 49 months (≈4.1 yrs). Twenty patients (60.6%) had ipsilateral recurrence, 8 (24.2%) had contralateral recurrence, and 5 (15.2%) had bilateral recurrence. The majority of these recurrence incidents (70%, 23/33) were reported at...
Conclusion
Women with personal history of breast cancer are at a very high risk of recurrence affected by heterogeneous patient and tumor factors that should be identified for each woman.
This study showed the influence by the women's personal reproductive history. Parity, family history and breast feeding were significantly impacting the rate of recurrence in women with conserving breast therapy. Such factors might require more frequent screening for earlier detection and diagnosis of recurrent disease.
Personal information and conflict of interest
I. Ewais; Al-Rehab City/ New Cairo/EG - nothing to disclose H. Gewefel; Cairo/EG - nothing to disclose L. Kassem; Cairo/EG - nothing to disclose K. Shohdy; Cairo/EG - nothing to disclose
Affiliation:
Hanan Gewefel1, Loay Kassem2, Kyrillus S. Shohdy2,3, Iman Ewais4
1 Assistant Professor of Diagnostic Radiology, Misr University of Science and Technology (MUST).
2 Clinical Oncology department, Cairo University hospital, Cairo, Egypt
3 Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medical College, NY, USA,
4 Breast Imaging Specialist, Breast Imaging Unit, Women and...
References
1.
Moy L et al: ACR appropriateness criteria stage I breast cancer: initial workup and surveillance for local recurrence and distant metastases in asymptomatic women. J Am Coll Radiol 2016, 13(11S):e43–e52
2.
Chansakul T,Lai KC,Slanetz PJ. The postconservation breast: Part 2, imaging findings of tumor recurrence and other long-term sequelae.Am J Roentgenol2012;198:331–343.
3.
Lowry, K.P., Braunstein, L.Z., Economopoulos, K.P.et al.Predictors of surveillance mammography outcomes in women with a personal history of breast cancer.Breast Cancer Res Treat2018; 171:209–215
4.
Kunkler IH, Kerr GR, Thomas JS et...