Appearance of suspicious microcalcifications: comparison between women under 40 and over 70 years old

Congress:

ECR 2020

Poster Number:

C-01673

Type:

Scientific Exhibit

Keywords:

Performed at one institution, Observational, Retrospective, Calcifications / Calculi, Biopsy, Mammography, Interventional non-vascular, Breast

Authors:

I. M. Sarachi¹, C. E. BELMUDES², A. L. TOLEDO², M. D. R. CEPEDAL², D. N. RICCI², M. L. RETONTARO²; ¹La Plata, Buenos Aires/AR, ²Buenos Aires/AR

DOI:

10.26044/ecr2020/C-01673

DOI-Link:

https://dx.doi.org/10.26044/ecr2020/C-01673

Fig. 1: Pieces of the vacuum pump required for the performance of biopsy: a needle...

Fig. 2: Images required to perform VABB

Fig. 3: 32 years old woman with clustered amorphous microcalcifications located in the...

Fig. 4: 35 years old female patient with clustered amorphous microcalcifications...

Purpose

Mammography is a low-dose x-ray procedure that allows visualization of the internal structure of the breast. The addition of breast tomosynthesis (TS, 3D mammography) to digital mammography reduce false positives and improve cancer detection compared to digital mammography alone. Therefore, screening mammography (SM) is the most effective tool to find breast cancer (BC), which vary by age. Annual SM in women ages 40-49 may lower the risk of dying from BC, but the benefit is less than for older women because they mostly have dense...

Methods and materials

An observational study performed during the period between January 2015 and May 2019 included 17 women under age 40 (age range 20-40 years; average age 30) and 17women over age 70 (age range 70-88 years; average 79), who underwent VABB for suspicious microcalcifications with a Digital Breast Tomosynthesis–guided Vacuum assisted Breast Biopsy (DBT-VABB). Breast was compressed with a fenestrated compressor with the patient in upright position. Target was located with DBT, lidocaine was used for local anesthesia, with 9 or 12 gauge needles and a...

Results

Of 427 biopsies: - 17 patients under age 40 (representing 3.9%) were performed DBT-VABB in order of frequency amorphous (12, 70.6%) (Fig 3, 4, 5), fine pleomorphic/linear (3,17.6%) (Fig 6, 7) and coarse heterogeneous (2, 11.8%) (Fig 8) microcalcifications. Histopathological results were 7 Atypical Ductal Hyperplasia (ADH), 4 sclerosing adenosis, 4 fibrocysticbreast disease (FBD), 3 Typical Lobular Hyperplasia (TLH), 2 Infiltrating Ductal Carcinoma (IDC), and 1 Ductal Carcinoma In Situ (DCIS). - 17 patients over age 70 were(3.9% of the total number of biopsies), presented...

Conclusion

Our results suggest that in both groups of ages were found most frequently clustered microcalcifications, and the main malignant pathology was IDC. As differences between them, in women under age 40 were found amorphous microcalcifications with bening results and high-risk breast lesions (these data differ from published studies) (10); and in women over age 70 were found amorphous and coarse heterogeneous microcalcifications with mainly malignant results and less number of high-risk breast lesions.

Personal information and conflict of interest

I. M. Sarachi; La Plata/AR - nothing to disclose A. L. Toledo; Buenos Aires/AR - nothing to disclose M. D. R. Cepedal; Buenos Aires/AR - nothing to disclose C. E. Belmudes; Buenos Aires/AR - nothing to disclose D. N. Ricci; Buenos Aires/AR - nothing to disclose M. L. Retontaro; Buenos Aires/AR - nothing to disclose

References

1) Komen Susan G (2016). Breast Cancer screening for women at average risk. Susan G Komen Foundation. https://ww5.komen.org/ 2) Girao Eugenio Deise Santiago, Souza Juliana A, Chojniak Rubens, Bitencourt Almir G. Graziano Luciana, Souza Elvira F. Breast cancer features in women under the age of 40 years. Rev Assoc Med Bras 2016; 62(8): 755-761. 3) Anders Carey K, Johnson Rebecca, Litton Jennifer, Phillips Marianne, Bleyer Archie. Breast Cancer Before Age 40 Years. Semin. Oncol. 2009; 36(3): 237-249. 4) Louise C. Walter, Schonberg Mara A. Screening...