Keywords:
Not applicable, Experimental, Education and training, Technical aspects, Chemotherapy, Arterial access, Percutaneous, Catheter arteriography, Oncology, Interventional vascular, Eyes, Interventional Radiology
Authors:
P. A. Rago1, J. Bartuszek2, E. Jurkiewicz1, U. H. Pasik1, J. Debska1; 1Warsaw/PL, 2Warszawa/PL
DOI:
10.26044/ecr2020/C-02090
Methods and materials
The IAC has been performed under anticoagulation with intravenous heparin (70units/kilo till 2018, 50 units per kilo from 2019) with a 3,5F leading catheter in ICA and 1,2-1,5 catheter placed at the entrance to the ophthalmic artery. A preinfusion arteriogram is taken to confirm patency of the ophthalmic artery.
Chemotherapeutic agents diluted in saline are delivered to retina using a pulsation technique. The selected chemotherapy drugs are Melphalan (2-5 mg) combined with Topotecan (0,3-1 mg). Carboplatin (20-40 mg) is used as well in most cases. Drugs combinations were modified for children with bilateral retinoblastoma (under 20%)
The patient’s age ranged from 4 months to 7 years. Each of them was given from 1 to 6 doses of chemotherapy (over 85% 3 doses).At this point children are not excluded from this procedure in terms of age and weight. Until 2019 children under 5 months, and under 7 kg were excluded from this procedure.
The effectiveness of this procedure is evaluated by a complete eye examination, as well as MRI Imaging.