Susac Syndrome is a rare disease and a better understanding of the disease is of clinical relevance.

In our experience, MRI is one of the keystones to diagnose Susac Syndrome.

White matter lesions with high signal in T2-weighted sequences, namely in the corpus callosum are the most common finding.

‘Snowball lesions’ in corpus callosum are typical but not demanding for the diagnosis.

Correct diagnose is essential once there are therapies that modify the disease course and improve the quality of life.