Measuring tumor size is a key parameter in TNM staging Discrepancy of tumor size measurement between pre-operative CT and pathology in lung cancer CT measurement tended to overestimate the pathologic size Previously, Goo et al. reported that regional lung attenuation (emphysema) surrounding the nodule had a significant effect on the solid nodule volume measurement Another study revealed local emphysema extent had no significant effect on volume variability when comparing inspiration and expiration CT and expiration causes a modest increase in nodule volume However, to date...

Patients Total of 268 SSNs in 252 patients were analyzed in the present study (Fig. 1) Clinical features Age, sex, and smoking history andpulmonary function test (PFT) CT image acquisition 128‐detector‐row scanners (750HD, General Electric, Milwaukee, WI, USA; Somatom Definition, AS, Siemens Medical Solution, Forchheim, Germany) Detector collimation, 1–1.25 mm; beam pitch, 1; rotation time, 0.8–1 seconds; tube voltage, 120 kVp; tube current, 200–300 mA; 1 mm section spacing; and 512 × 512 pixel resolution, slice thickness of 1.25 or 2 mm End of full...

Patient demographics (Table. 1) The proportion of men and smokers was significantly higher in the emphysema group than in the normal lung group Age, smoking pack‐years (PYRs), and emphysema score were significantly higher in the emphysema group PFT, forced expiratory volume in 1 second (FEV1) and FEV1/forced vital capacity (FVC) were significantly lower in the emphysema group than in the normal lung group No significant differences in nodule morphology, WTsize, STsize, or clinical T‐stage between the emphysema and normal lung groups Comparison of whole tumor...

WTsize of SSNs tended to overestimate the Psize, and these differences were less prominent in the emphysema group than in the normal lung group CT measurement reflects the size in an expanded lung. In pathologic measurements, lung specimens were deflated after formalin fixation Emphysema causes a larger difference in STsize between TSCT and pathology STsize < Psize Emphysema may reduces lung attenuation around the tumor and decreases the density of subsolid nodule Concordance rates of Clinical and Pathologic T staging was lower in emphysema group(61.7%,...

J. Bae; Daegu/KR - nothing to disclose H. Park; Daegu/KR - nothing to disclose J.-K. Lim (corresponding author); Daegu/KR - nothing to disclose H. J. LEEDaegu/KR - nothing to disclose S. Y. Lee; Daegu/KR - nothing to disclose H. Lee; Daegu/KR - nothing to disclose M. H. Hahm; Daegu/KR - nothing to disclose

1.Zhang J, Gold KA, Lin HYet alRelationship between tumor size and survival in non–small‐cell lung cancer (NSCLC): An analysis of the surveillance, epidemiology, and end results (SEER) registry.J Thorac Oncol2015;10: 682–90. 2.Goldstraw P, Chansky K, Crowley Jet alThe IASLC lung cancer staging project: Proposals for revision of the tnm stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer.J Thorac Oncol2016;11: 39–51. 3.Rami‐Porta R, Bolejack V, Crowley Jet alThe IASLC lung cancer staging project: Proposals for the revisions of the T...