Measuring tumor size is a key parameter in TNM staging

Discrepancy of tumor size measurement between pre-operative CT and pathology in lung cancer

•  CT measurement tended to overestimate the pathologic size

Previously, Goo et al. reported that regional lung attenuation (emphysema) surrounding the nodule had a significant effect on the solid nodule volume measurement

Another study revealed local emphysema extent had no significant effect on volume variability when comparing inspiration and expiration CT and expiration causes a modest increase in nodule volume

However, to date there has no investigation regarding the effect of emphysema on the size discrepancy between CT and pathology

To investigate how the presence and severity of emphysema could influence the discrepancy of measurements between CT and pathology in lung adenocarcinomas presenting as subsolid nodules