To assess multi-component analysis derived from ultrashort echo time magnetic resonance imaging (UTE-MRI).
We demonstrated that brain component analysis based on T2 measurement depends on lipid signal.
Ultrashort Echo Time Magnetic Resonance Imaging (UTE-MRI) is a technique using extremely short-TE(s) which enables the observation of a component signal having a short T2. In clinical practice, the shortest TE is set at between 0.04–1.0 ms, which is used for the imaging of cartilage and Achilles tendon (T2 = 0.3–0.7 ms); furthermore, bone, lung, and brain imaging are also used.
Myelin is a membrane structure rich in lipid components that wrap around nerve cell axons. The components are 70–80% lipid and 20–30% protein ....
Findings and procedure details
Fig. 1 shows the procedure for producing a MWF image. On a 3.0 Tesla MR scanner system (Discovery MR750, GE Healthcare, Waukesha, WI, USA) and a standard head coil receiver, a healthy volunteer (24-year-old male) study was performed using three-dimensional spoiled gradient-echo (3D-SPGR) with and without FS. The imaging parameters were as follows: TE, 0.032, 2.2, 4.6, 6.9, and 10 ms; repetition time (TR), 265.1 ms; field of view, 200 mm; matrix size, 256×256; band width, 976.6 kHz; slices, 26; slice thickness, 5 mm; flip...
It was found that multi-component analysis of the brain using UTE-MRI affected the lipid signal of WM structures.
Personal information and conflict of interest
Corresponding Author info:
Yuki Kanazawa, PhD
3-18-15 Kuramoto-cho, Toksuhima City, Tokushima, 770-8503, Japan
Tel: +81 88 633 9059
Fax: +81 88 633 9059
E-mail: [email protected]
Authors declare that they have no conflicts of interest. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
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