In total 44 Participants with suspected cognitive impairment were admitted to the neurologist and the Montreal Cognitive Assessment (MoCA)⁵ was carried out. Participants were divided into 3 groups:

• 11 participants with normal cognition (MoCA scores≥26; Average MoCA scores 27.3, SD 1.0; average age 73.2, SD 5.5),
• 23 participants with mild cognitive impairment (MoCA scores≥18 and ≤25; Average MoCA scores 22.4, SD 2.4; average age 72.3, SD 6.5),
• 10 participants with dementia (MoCA scores≤17; Average MoCA scores 10.1, SD 4.1; average age 74.8, SD 10.4).

MRI scans were performed on a 3T scanner.  Post-processing with cortical reconstruction and volumetric segmentation was performed with the Freesurfer image analysis suite, which is documented and freely available for download online (http://surfer.nmr.mgh.harvard.edu/).^{3, 4}

We evaluated hippocampal volume and Alzheimer's disease cortical signature regions and performed the Kruskal-Wallis test with post hoc analysis. Alzheimer's disease cortical signature regions^1,2 included:

• the entorhinal cortex,
• temporal lobe medial aspect (separately analyzing fusiform gyrus and parahippocampal gyrus),
• inferior temporal gyrus,
• superior frontal gyrus,
• inferior frontal gyrus (separately analyzing orbital, triangular, and opercular gyrus),
• supramarginal gyrus,
• superior parietal lobule,
• precuneus.