The correlation between max.SUV of 18F-FDG PET/CT with tumor size, T stage and patients’ demographics in non-small cell lung cancer

Congress:

ECR 2022

Poster Number:

C-10341

Type:

Educational Exhibit

Keywords:

Hybrid Imaging, Lung, Nuclear medicine, CT, PET-CT, Biopsy, Staging, Cancer, Neoplasia, Pathology

Authors:

S. M. I. Y. Shalaby, E. Darwish, M. Gamal, A. Rashad, E. Neri

DOI:

10.26044/ecr2022/C-10341

DOI-Link:

https://dx.doi.org/10.26044/ecr2022/C-10341

Conclusion

Discussion:

Computed tomography (CT) of the chest has been the workhorse for establishment of the precise anatomical and morphological information. Though, (FDG) PET/CT acquired an increased dependance for the diagnosis and staging of lung cancer.^[7]

The metabolic activity represented by (FDG) uptake is now considered to be a prognostic factor in patients with lung cancer ^[7,8]. Meaning that patients with positive FDG-PET-CT results in treated lung cancer had a significantly worse prognosis than patients with negative results. [9]. In our study, we explore whether max.SUV of the primary lung mass tumor correlates with its size as well as its T-stage in patients with non-small cell lung cancer (NSCLC). Our study demonstrated a statistically significant positive correlation between the primary tumor size and its metabolic activity expressed by max.SUV of (FDG) uptake. Meaning that, the larger the tumor, measuring ≥5 cm, the higher the possibility of (FDG) metabolic activity. Similarly, Doom et al. and Karam et al ^[1,10] also reported a significant correlation between tumor size and max.SUV in patients with NSCLC. Um et al. ^[11] have also illustrated that in patients with stage I NSCLC there was a significant association between the primary tumor’s max.SUV and tumor size; with tumors ≤ 5 cm having a significantly lower SUV than tumors > 5 cm.

Our data showed that there is no significant correlation noted between the age or sex of the patient and the primary lung mass pathology type. In addition, there was no significant statistical difference between mean max.SUV of males and females, which are in concordance with the results of Karam et al. There is also no significant correlation noted between the max.SUV of the tumor and the T-stage of it.

Conclusion:

Max.SUV concluded to be associated with primary lung tumor size, Thus, max.SUV can reflect the (FDG) metabolic activity of the tumor, thus, the overall max.SUV of patients with NSCLC could be predicted by tumor size value. Yet larger prospective and randomized analyses can potentially reveal more significant relationships.

Fig 1: 18F-FDG PET/CT images of a patient with SCC. A: fused axial CT chest showing...

Fig 2: Table (1) shows descriptive data of the whole study population.

Fig 3: Table (2): comparison of patient`s age according to pathology type

Fig 4: Table 3: showing the number and percent of patient`s gender among different...

Fig 5: Table (4): T Staging of the study population

Fig 6: Table (5): comparison of tumor size according to pathology type

Fig 7: Table (6): comparison between two pathologies according to tumor size