Multiple sclerosis (MS) is a progressive neurological disorder that causes physical and cognitive disabilities. [1]In the United States, about 400,000 people are currently diagnosed with MS, but it is estimated that there may be about 2.5 million people worldwide suffering from MS. The disease usually begins in early adulthood, the prognosis is variable with 50% of patients needing assistance to walk in a 15-year period. The process of diagnosing and understanding MS requires a multidisciplinary team consisting of specialists from neurology, immunology, radiology, and many...

In total, 30 patients diagnosed with MS by the Department of Neurology of the Pauls Stradins Clinical University Hospital were enroled in this retrospective cohort study. 53.3% (n=16) of our study group were women, but 46.7% (n=14) were men.The age of the patients ranged from 25 to 59 years, with a median age of 46 years (IQR 36-48).Exclusion criteria were patients with other central nervous system diseases, suboptimal MRI images and artifacts in MRI images that could influence the results of brain volume analysis. Brain...

Baseline EDSS ranged between 1 and 6, median 1.5 (IQR 1.5-2.0), after 5 years EDSS ranged between 1 and 7, median 2.5 (IQR 2.0-3.0), p<0.001. We found significantly lower volumetry results in different areas of the brain including both cortical and total gray matter p<0.001, middle-posterior part of the corpus callosum, p<0.001, white matter, p<0.05 and thalamus, p<0.05. [Table 1] [Fig 2] [Fig 3] [Fig 4] In our study population, the middle-posterior part of corpus callosum showed the lowest volumetry results among patients whose EDSS...

Brain atrophy is associated with the degree of disability in patients with MS. Our study suggests that magnetic resonance volumetry results are significantly related to disability progression. Atrophy in the middle-posterior part of the corpus callosum could be the most favorable biomarker. The results indicate that there is a negative moderate correlation between the changes in the volume of the total cortical gray matter, total gray matter, total cerebral white matter right hippocampus volume and the EDSS after 5 years - as the volume of...

D. Grabovska: Nothing to disclose A. Balodis: Nothing to disclose E. Naudins: Nothing to disclose S. Strautmane: Nothing to disclose A. Teivāne: Nothing to disclose E. Fisermans: Nothing to disclose D. Urbanovics: Nothing to disclose J. Mednieks: Nothing to disclose A. Millers: Nothing to disclose

[1] C. C. Hemond and R. Bakshi, “Magnetic Resonance Imaging in Multiple Sclerosis,” Cold Spring Harb Perspect Med, vol. 8, no. 5, May 2018, doi: 10.1101/CSHPERSPECT.A028969. [2] E. Marciniewicz, P. Podgórski, M. Sasiadek, and J. Bladowska, “The role of MR volumetry in brain atrophy assessment in multiple sclerosis: A review of the literature,” Advances in Clinical and Experimental Medicine, vol. 28, no. 7. Wroclaw University of Medicine, pp. 989–999, 2019. doi: 10.17219/acem/94137. [3] R. Dobson and G. Giovannoni, “Multiple sclerosis – a review,” Eur J...