Novel use of contrast-enhanced susceptibility imaging (CE-SWI) in assessing treatment response in extremity soft-tissue undifferentiated pleomorphic sarcoma (UPS)

Congress:

ECR 2024

Poster Number:

C-11059

Type:

Scientific Exhibit

Keywords:

Musculoskeletal soft tissue, MR, MR-Functional imaging, Computer Applications-Detection, diagnosis, Cancer

Authors:

R. F. Valenzuela, E. Duran-Sierra, M. Canjirathinkal, C. Costelloe, J. Madewell, W. Murphy, B. Amini

DOI:

10.26044/ecr2024/C-11059

DOI-Link:

https://dx.doi.org/10.26044/ecr2024/C-11059

Conclusion

The high-order radiomic analysis at PRT found 2 texture features with the highest significance separating Good vs. Partial/Non-Responders.
CE-SWI "Complete Ring" morphology was the most common and statistically associated pattern observed in Good Responders at PRT.
The results from the UPS radiomic analysis across multiple treatment time points displayed statistically significant radiomic features that could potentially serve as imaging biomarkers of good response in patients.

Fig 1: SWI image processing workflow developed in this study.

Fig 2: CE-SWI morphological patterns across treatment.

Fig 3: Representative CE-SWI post-radiation morphology patterns.

Fig 4: Morphological patterns of CE-SWI at post-radiation by response.

Fig 5: Complete hemosiderin ring as a UPS CE-SWI pattern of response.

Fig 6: Radiomics of CE-SWI ring morphology.

Fig 7: UPS CE-SWI radiomics at post-chemotherapy (PC).

Fig 8: UPS CE-SWI radiomics at post-radiation (PRT).