POSTER SECTIONS Coverpage Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References

ECR 2024 / C-11064

Thoracic involvement in diseases related to dysregulated humoral immunity

Congress:

ECR 2024

Poster Number:

C-11064

Type:

Educational Exhibit

Keywords:

Haematologic, Mediastinum, Respiratory system, CT, Complications, Infection

Authors:

J. G. Maluf, J. F. Maluf, T. R. Yamanari, H. Lee, T. Lima, D. Cardoso, V. D. Bichuette, R. V. Auad, M. V. Y. Sawamura

DOI:

10.26044/ecr2024/C-11064

DOI-Link:

https://dx.doi.org/10.26044/ecr2024/C-11064

Learning objectives

To provide a comprehensive overview about the chest involvement in dysregulated humoral immunity states, including a review about the main pathologies related, allowing to identify their thoracic manifestations and recognize the imaging findings.

Background

A case-based review that will illustrate different clinical scenarios regarding the chest involvement in states of dysregulated humoral immunity, including cases about the main diseases related, chest manifestations and imaging features.

Findings and procedure details

A)INTRODUCTION States of dysregulated humoral immunity are characterized by ineficiency of antibody activity or production. In this scenario, the human organism becomes more succeptible to diverse complications, specially infectious ones. However, non-infectious complications may also occur and can be extreamelly harmfull. Various diseases can compromise humoral immunity and lead to those complications, affecting multiple systems and parts of the human body. The thoracic involvement is very common and related to big morbidity and mortality. [Fig 1] B)GENERAL CONCEPTS The immune system is a network of...

Conclusion

Thoracic involvement is often found in states of dysregulated humoral immunity. Chronic changes and infections are an import cause of mortality in those patients. Imaging, especially CT, plays an important role in diagnosis, management, and evaluation of treatment’s response. Radiologists should be familiar with the imaging features and thoracic manifestations related to dysregulated humoral immunity.

Personal information and conflict of interest

J. G. Maluf: Nothing to disclose J. f. Maluf: Nothing to disclose T. R. Yamanari: Nothing to disclose H. Lee: Nothing to disclose T. Lima: Nothing to disclose D. Cardoso: Nothing to disclose V. D. Bichuette: Nothing to disclose R. V. Auad: Nothing to disclose M. V. Y. Sawamura: Nothing to disclose

References

1. Bierry G et al. Thoracic manifestations of primary humoral immunodeficiency: A comprehensive review. Radiographics 2009; 29:1909-1920 2. Uzunhal Y et al. The lung in dysregulated states of humoral immunity. Respiration 2017; 94: 389-404 3. Cinetto F et al. Granulomatous lymphocitic interstitial lung disease (GLILD) in common variable immunodeficiency (CVID): A multicenter retrospective study of patients from italian PID referral centers. Frontiers in Immunology 2021; 12: 627423 4. Bonilla FA, Barlan I, Chapel H, Costa-Carvalho BT, Cunningham-Rundles C, de la Morena MT, et al. International...

Fig 1: Example of pathologies that compromise humoral immunity and affect the chest.

Fig 2: Differences between innate and adaptive immunity.

Fig 3: Differences between humoral and celullar immunity.

Fig 4: Thoracic findings related to states of dysregulated humoral immunity.

Fig 5: CT findings related to states of dysregulated humoral immunity.

Fig 6: Male, 25y/o, with CVID and recurrent respiratory infections, presenting...

Fig 7: Male, 58y/o, with CVID and recurrent respiratory infections, presenting...

Fig 8: Male, 23y/o with CVID presenting ground glass opacities predominating at the...

Fig 9: Male, 23y/o, with CVID and recurrent respiratory infections, presenting...

Fig 10: Male, 33 y/o, with CVID and bronchiectasis, presenting cough and dyspnea. At...

Fig 11: Male, 48y/o, with CVID and recurrent respiratory infections, presenting...

Fig 12: Female, 22y/o, with CVID and GLILD, presenting diffuse multiple ...

Fig 13: Female, 15y/o, with CVID and GLILD, presenting multiple perilymphatic...

Fig 14: Female, 64y/o, with hypogammaglobulinemia and GLILD, presenting diffuse...

Fig 15: Female, 43y/o, with IgG4-RD presenting Usual Interstitial Pneumonial (UIP)...

Fig 16: Female, 53y/o, with IgG4-RRD presenting scattered nodules throughout the lungs,...

Fig 17: Male 43 y/o, with IgG4-RRD presenting pleural thickening ai the lung bases...

Fig 18: Male, 68y/o, with IgG4-RD confirmed by pancreatic biopsy presenting a right...

Fig 19: Female, 68y/o, with Multiple myeloma and Pulmonary LCDD presenting diffuse...

Fig 20: Male, 70y/o, with Chronic Lymphocitic Leukemia presenting diffuse cysts within...

Fig 21: Female, 56 y/o, with Respiratory Amiloidosis presenting septal thickening,...

Fig 22: Male, 61 y/o, with Respiratory Amiloidosis presenting sparse pulmonary nodules,...