Metabolic disorders, Diagnostic procedure, MR, Cardiac
C. M. Berzovini1, R. Faletti2, M. Gatti2, E. Caramia2, E. Vanni1; 1Torino/IT, 2Turin/IT
The analysis of glucose metabolism and anthropometric parameters showed a relevant difference of body mass index (BMI) between NAFLD patients and control group (BMI NAFLD patients: 27 kg/m2 vs 22 kg/m2); a difference in insulin sensibility and resistance indexes was also found (HOMA index NAFLD patients: 2,82 ± 1,7 vs 1,43 ± 0,5; p= 0,034.
OGIS index NAFLD patients: 11,04 ± 1,6 vs13,1 ± 1,1; p= 0,004).
In patients’ group the volume of epicardial fat tissue measured with MRI was increased if compared with the control group (185±109 vs 52±30 cm3; p<0.0001),
as well as its thickness measured with TTE (6.2±2.5 vs 2.8±3.5 mm; p=0.001). A direct positive correlation between epicardial and visceral adipose tissue was found in the subgroup of patients (n=13) who underwent the abdominal examination with MRI (r= 0.58; p = 0.03).
Left ventricular ejection fraction was not statistically different between the groups,
in both TTE and MRI evaluation ((52,3 ± 5,9 vs 55,2 ± 7,6; p= 0,36).
In NAFLD patients’ group,
TTE showed an increased end-systolic left ventricular diameter (30±4 vs 27±4 mm; p=0.015),
even though MRI did not point out a significant difference in end-systolic volume between the two groups (75.4±29.8 vs 80.5±31.6 ml; p=0.81).
TTE showed that E/A ratio,
a diastolic dysfunction parameter,
is reduced in NAFLD patients (1.2±0.3 vs 1.5±0.4; p=0.03).
The 1st/2nd filling volume ratio measured with MRI using volume/time curves analysis was significantly reduced in NAFLD patients (1.6±1.5 vs 3.1±1.8; p=0.04).