In early stages of osteoarthritis there is an imbalance of cartilage metabolism associated with loss of proteoglycans,
disruption of collagen fiber microstruture and an increase of cartilage water content.
Advanced stages of cartilage degeneration are associated with a loss of free water content of the cartilage.
Changes in cartilage microstructure lead to irreversible damage of cartilage causing osteoarthritis.
There are several quantitative mri mapping sequences,
such as T2* mapping which allow assessment of articular cartilage mircostructure such as free water content and therefore can be...
Methods and Materials
Four experienced skiers aged 20 to 58 years were included in this feasibility study which was conducted in Lech,
MRI examinations of both knees including T2*-mapping sequences were acquired of every test person before skiing (baseline),
one hour (follow up 1) and four hours (follow up 2) after skiing and after recovery overnight.
Initially two test subjects used either a conventional ski binding system or ACTRI F respectively.
After recovery time of one week study procedure was repeated using the respective other ski binding...
All MR-examinations could be acquired at the scheduled time-slots.
The average measurement time for both knees was 25 minutes.
The delay between skiing and the acquisition of the T2* mapping data in follow-up 1 and follow up 2 was predominantly less than 10 minutes.
Differences in T2* time (ms) compared to initial individual baseline (baseline 1),
follow up 1 and 2 (fu 1-1 and fu 1-2),
baseline at the following weekend (baseline 2) and follow up 1 and 2 (fu 2-1 and fu...
In this feasibility study changes of T2*-time of the femorotibial and femoropatellar cartilage could be detected under mechanical loading caused by skiing.
These differences most likely represent mechanical effects on cartilage microstructure such as water content.
Larger studies are necessary to prove our findings.
T2* mapping of hip joint cartilage in various histological grades of degeneration.
T2* mapping of acetabular and femoral hip joint cartilage at 3 T: a prospective controlled study.
Degenerative joint disease.
Sebastian Kleiner Consultant at the Department of Radiology of the University Hospital Ulm,
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