Neoplasia, Lymphoma, Diagnostic procedure, Plain radiographic studies, MR, CT, Musculoskeletal system, Musculoskeletal bone
N. S. Sideri1, S. Argentos2, I. Papanastasiou2, S. Papageorgiou2, P. Papagelopoulos2, K. Palialexis2, N. L. Kelekis2, O. Papakonstantinou2; 1Chaidari/GR, 2Athens/GR
PBL/PML are malignant neoplasms with varied radiographic appearance,
A high index of suspicion is required to minimize delayed diagnosis and misdiagnosis.
Osseous lymphoma might appear normal or demonstrate subtle findings on radiographs but may have a sonorous appearance on other studies.
Further imaging is necessary to unmask underlying marrow disease.
MRI remains the key imaging technique,
both in the diagnostic and differential-diagnostic procedure.
We should always consider lymphoma when encountering a poorly-defined sclerotic or mixed sclerotic/lytic bone lesion,
demonstrating locally aggressive behavior.
Imaging also plays an important role in assessing response to treatment and planning further therapeutic management in both PBL and PML.
As primary musculoskeletal lymphoma remains a rare entity,
though highly curable,
it is important to be differentiated from other causes of lytic or sclerotic bone lesions,
such as other primary bone tumors,
metastases and infectious disease.