Purpose
To study the correlation of HRCT findings with DLCO in patients with IPF and analyse the role of HRCT in grading severity of the disease.
Methods and Materials
Materials & Methods:
Cross sectional study .
30 patients with IPF were included in the study.
Retrospective study.
Inclusion Criteria:
P F Ts with evidence of restriction and impaired gas exchange.
HRCT – bilateral basal reticulation / honeycombing.
Dyspnea of insidious onset and unknown cause .
Duration of illness > three months
Bilateral basal crepitations
Age older than 35 years.
Exclusion Criteria:
Individuals with asthma
Lung disease due to exposures,
drugs,
and connective tissue diseases
Equipment Used
Somatom Sensation Siemens 64 slice.
Quark P.F.T.
(Cosmed...
Results
Fig-5: Study population
In this study,
consisting of 30 IPF patients,
13 were female (43%),
and 17 were male(57%)
Mean ageof the study sample was 60.7.
Fig-6:Study population- Age distribution
Table-1 : HRCT findings in the 30 patients with IPF.
HRCT findings
Affected patients
%
Reticular abnormality
30
100
Honeycombing
26
86
Honeycombing ,
Cysts ↓3mm
26
86
Honeycombing ,
Cysts ↑3mm
13
43
Traction bronchiectasis
29
96
Associated significant emphysema
7
23
Peripheral distribution /sub pleural predominance of lesions seen in all patients.
Table-2:Mean...
Conclusion
Total lung involvement showed strongest correlation with percentage of predicted DLCO.
It is possible to grade the severity of IPF based on the TID scores,
with a cut off value of six,
to separate advanced and limited disease,
with a sensitivity of 85% and specificity of 65%.
Emphysema was found to be a factor,
which caused the FVC values not to decrease as expected for a restrictive disease like IPF.
This shows that concurrent emphysema in IPF patients can lead to spurious interpretation and diagnosis...
References
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A.
U.,
Rubens,
M.
B.,
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R.
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Lone cryptogenic fibrosing alveolitis: a functional-morphologiccorrelation based on extent of disease on thin-section computed tomography.
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Personal Information
Prof.
P V Ramachandran
Dept of Radiodiagnosis,
Amrita Institute of Medical Science,
Kochi,
Kerala,
India.