This poster was originally presented at the RANZCR Annual Scientific Meeting 2011, October 6-9, in Melbourne/AU.
Congress:
RANZCR ASM 2011
Keywords:
Paediatric, Neuroradiology brain, MR physics, MR, MR-Diffusion/Perfusion, Congenital, Genetic defects
Authors:
S. Bhuta, C. Hsu, G. Kwan; Gold Coast/AU
DOI:
10.1594/ranzcr2011/R-0109
Methods and Materials
Three patients with clinical diagnosis of Joubert syndrome were recruited into the study.
Their age was 4 year old male,
4 month old male and a 4 month old female.
The clinical findings are presented in Table 1.
Two healthy,
aged and sex matched volunteers with no medical history were used as control subjects.
Informed consent was received from all participants’ parents and all procedures were performed with the approval of the institutional review board for clinical studies.
MRI was performed on a 1.5 T MRI system (SIEMENS MAGNETOM SymphonyTim syngo MR B18).
Multiplanar T2- and T1-weighted imaging was performed in all patients as a routine screening.
Diffusion tensor imaging (DTI) was obtained in two of the three JS patients and two age-matched control subjects.
DTI scanning parameter were 23 slices,
FoV read 230 mm,
slice thickness of 5.0 mm and alone 20 different geometric directions.
Isotropic diffusion-weighted images,
apparent diffusion coefficient (ADC) maps,
color-coded fractional anisotropy (FA) maps were calculated.
FA color vector maps were used to place a region of interest for fiber tracking.