Background. Cancer related fatigue (CRF) is the most commonly reported adverse side effect of cancer treatment and is estimated to affect between 70-100% of patients1,2. The persistent tiredness associated with CRF is experienced during and after treatment and has a significant negative impact on quality of life3. Although counterintuitive to many patients and clinicians, current research evidence suggests that exercise is an effective strategy for managing CRF4,5-7. Importantly, it has been clearly demonstrated that exercise during and/or after cancer treatment does not exacerbate CRF5-7. The...

Assesment time intervals: baseline (pre-RT) end of RT 6weeks post RT 6 months post RT 12 months post RT Participants: n=87 breast cancer patients prescribed radical breast radiotherapy exclusion criteria- metastatic disease, comorbidities prohibiting pt from exercising, reasonable grasp of English to complete questionnaire Study Endpoints: fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue) Physical Activity Level (Godin Leisure Time Exercise Questionnaire Quality of Life (Short Form-36 Health Survey) Exercise Intervention: home based exercise programme- aerobic, resistance & flexibility exercise prescription (individualised) 1 hour face-to-face consultation...

BASELINE CHARACTERISTICS EXERCISE (N=43) USUAL CARE (N=44) P-VALUE Age (years) 52.2 +/-10.6 51.8 +/-10.9 0.711 Tertiary Education 12 (28%) 22 (50%) 0.035 Employed 25 (58%) 31 (70%) 0.090 Number of co-morbidities* 0.5+/-0.6 0.8+/-1.1 0.046 Previous chemotherapy 25 (58%) 27 (61%) 0.664 Radiation Dose to breast (Gy) 49.2 +/-2.4 49.3 +/-2.3 0.744 Number of radiation fractions 24.1 +/- 2.7 24.2 +/- 2.6 0.836 physical activity level -meet aerobic exercise guidelnes 10 (23%) 13 (30%) 0.506 -meet resistance exercise guidelines 4(9%) 4 (9%) 0.973 STUDY SCHEMA METHODS...

Yvonne Zissiadis: Genesis Cancer care WA, Edith Cowan University Prue Cormie, Carolyn Peddle-McIntyre, Daniel A Galvao, Robert U Newton: Edith Cowan University Health and Wellness Institute, ECU, Joondalup, WA Margaret Latham, Sema Cakan, Sharon Ray: Genesis Cancer Care WA

1. De Waele S, Van Belle s. Cancer-related fatigue. Acta Clin Belg. 2010;65(6):378-85. 2. Ahlberg K, Ekman T, Gaston-Johansson F, et al. Assessment and management of cancer-related fatigue in adults. Lancet. 2003 Aug 23;362(9384):640-50. 3. Hartvig P, Aulin J, Hugerth M, et al. Fatigue in cancer patients treated with cytotoxic drugs. J Oncol Pharm Pract. 2006 Sep;12(3):155-64. 4. McNeely ML, Courneya KS. Exercise programs for cancer-related fatigue: evidence and clinical guidelines. J Natl Compr Canc Netw. 2010 Aug;8(8):945-53. 5. Cramp F, Daniel J. Exercise for...