•To identify clinical and imaging patterns of demyelinating disorders •Can MRI assist in characterizing and differentiating various CNS demyelinating disorders

Inflammatory demyelination disorders of the CNS are a broad group of disorders that involve acute on chronic autoimmune destruction CNS neuroglia. These are relatively common in Caucasians compared to Asian and African-American populations. These disorders vary in terms of their epidemiology, pattern of disease presentation, pathology, imaging findings and prognosis. Multiple Sclerosis (MS): MS is the most common form of chronic demyelinating diseases of the CNS. It has a lifetime incidence of 0.1% and is more common among siblings of affected patients (up to 25%)...

MRI features of demyelination: Demyelinating lesions can be broadly classified into grey matter, white matter, optic nerve and spinal cord lesions. White matter lesions are the most common lesions found in demyelinating disorders. These lesions appear hyperintense on T2WI. While this is a sensitive finding, it is hardly ever specific if taken in isolation. FLAIR sequences improve tissue contrast by suppressing the signal from CSF, making juxtacortical lesions easier to identify. T1WI can initially appear normal, however in some patients the plaques appear hypointense. These...

Inflammatory CNS demyelination disorders have unique Imaging findings and correlate well with clinical presentation. Knowledge of imaging features, lab findings in each is essential for accurate diagnosis as it significantly alters patients’ management and prognosis.

Correspondence to, Dr.Sandeep Bhuta Senior Neuroradiologist Director of Research / MRI Supervisor Dept.of Medical Imaging1 Hospital Boulevard, Gold Coast University Hospital, Associate Professor, School of Medicine&Menzies Health Institute, GriffithUniversity Gold Coast, QLD,4215 Australia [email protected]

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