Keywords:
Lung, Oncology, PET-CT, Radiation therapy / Oncology, Cancer, Outcomes
Authors:
N. Lee1, J. Shafiq1, M. Field1, C. Fiddler2, S. Varadarajan3, S. Gandhidasan2, E. Hau3, S. Vinod1; 1Sydney, NSW/AU, 2Wollongong, NSW/AU, 3Blacktown, NSW/AU
DOI:
10.26044/ranzcr2021/R-0268
Methods and materials
Population
Data from inoperable stage I-III NSCLC patients diagnosed from 1/1/2016-31/12/2017 were retrospectively collected from three radiation oncology clinics. The development cohort comprised patients from South Western Sydney Local Health District (SWSLHD). The validation cohort included patients from Blacktown Cancer and Haematology Centre (BCHC) and Illawarra Cancer Care Centre (ICCC).
Data and statistical analysis
Patient, tumour and treatment-related variables were selected for model inclusion using univariate and multivariate analysis. Cox proportional hazards regression was used to develop a 2-year survival prediction model in one clinic (n=157) and validated in the other clinics (n=155). The South West Sydney Model (SWSM) was developed in the overall population and the Radiotherapy South West Sydney Model (R-SWSM) was developed in patients who received radiotherapy. A scoring system for the models was generated using the logarithm of the odds ratio (OR) to allocate points for each variable. Model performance, assessed internally and on two independent datasets, was expressed as Harrell’s concordance-index (c-index).