Keywords:
Lung, Oncology, PET-CT, Radiation therapy / Oncology, Cancer, Outcomes
Authors:
N. Lee1, J. Shafiq1, M. Field1, C. Fiddler2, S. Varadarajan3, S. Gandhidasan2, E. Hau3, S. Vinod1; 1Sydney, NSW/AU, 2Wollongong, NSW/AU, 3Blacktown, NSW/AU
DOI:
10.26044/ranzcr2021/R-0268
Results
The characteristics of the study population are summarised in Table 1.
The SWSLHD population consisted of 157 patients in the overall cohort and 117 patients in the radiotherapy cohort. At the censor date, 45.9% and 47.9% of patients were alive in the overall and radiotherapy cohorts respectively.
The SWSM variables consisted of diffusing capacity of the lung for carbon monoxide, T stage and treatment intent. The R-SWSM included overall stage, tumour lobe and treatment intent. The SWSM and R-SWSM yielded c-indexes respectively of 0.65 and 0.66 on internal validation and 0.65-0.71 and 0.64-0.65 on external validation. Both models outperformed survival predictions (c-index) made using TNM staging alone.
Survival probability could be stratified into three groups using a risk score derived from the models (Table 2).
Kaplan-Meier curves by risk group and cohort for the SWSM and R-SWSM are presented in Figure 3 and Figure 4 respectively.
Log-rank test identified significant differences (p<0.05) between subgroups across all cohorts.