Purpose
Evaluation of cardiac magnetic resonance imaging (MRI) accuracy in pre-clinical stage of hypertrophic cardiomyopathy (HCM) patients compared to echocardiography.
Cardiac morphology and function parameters of ventricular wall thickness (wt),
mass (m),
left ventricular end-diastolic volume (EDV),
and ejection fraction (EF) measurements were assessed by these two techniques.
Methods and Materials
A total of seven subjects (6 females and 1 male,
age 48 ± 16 years),
who were genotype positive for hypertrophic cardiomyopathy in pre-clinical stage with no history of cardiac or respiratory symptoms were studied with demographics shown in Table 1.
The cardiac morphologies were measured by means of cardiac MRI,
and echocardiogram.
The morphological parameters of ventricular wall thickness at basal and apical segments of the left ventricle in anteroseptal,
and inferolateral regions,
as well as cardiac mass measurements were obtained.
MRI datasets were...
Results
MRI in cardiac morphological evaluation in pre-clinical-HCM stage in particular ventricular wall thickness assessment revealed to be superior to the echocardiogram with narrower limit of agreement.
Echocardiography underestimated the wall thickness at anteroseptal and inferolateral segments.
The cardiac mass measurements revealed good correlation between MRI and echocardiogram (r: 0.92),
as shown in Fig. 1 .
MRI assessment of EDV correlated well with measurements acquired with echocardiogram (r: 0.81),
but volumes measured by MRI were slightly overestimated with wider limit of agreement (SD: 11ml).
The EF...
Conclusion
Accuracy of ventricular wall hypertrophy and LVEDVmeasurements are important in detection of early changes in pre-clinical HCM.
These parameters have shown to be accurately measurable by MRI,
although EDV-measurements were slightly overestimated by MRI.
The morphological evaluations in particular measurements of ventricular wall thickness proved to be more accurate by MRI than echocardiogram.
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