To demostrate atypical imaging appearances of DLBCL in HIV patients To differentiate lymphoma from lymphadenopathy of infectious aetiology in the setting of HIV

Non-Hodgkin’s Lymphomas (NHL), which include high-grade diffuse large B-cell lymphoma (DLBCL)are the second most common malignancy in people with HIV/AIDS (1). NHL, Kaposi sarcoma (KS) and cervical cancers are considered to be AIDS-defining malignancies. Epstein Barr virus (EBV) is an oncogenic virus which causes the two most common AIDS-associated NHL subtypes (DLBCL and central nervous system NHL) (2). DLBCL in HIV-infected patients is associated with immunosuppression, and the risk increases with declining CD4 count. AIDS-defining malignancies account for 15%-19% of all deaths in HIV-infected patients...

In the setting of HIV, high grade DLBCL has atypical imaging appearances which can sometimes be confused with infectious disease or other malignancies. The following cases highlight these atypical findings in solid and hollow abdominal viscera and bone. Case 1: A 54-year-old lady presented with history of abdominal pain and jaundice. She had recently commenced on highly active antiretroviral therapy (HAART). Initial CD4 count was 48/mm3. Imaging with contrast enhanced CT (fig.1) revealed a heterogenous mass arising from the head and uncinate process. It measured...

HIV-AIDS related DLBCL can have atypical CT findings on imaging. It is important for radiologists to be aware of these atypical presentations so as to help differentiate them from other malignancies or infection related etiologies which are also common in this subset of patients.

Goedert, J. J., Coté, T. R., Virgo, P., Scoppa, S. M., Kingma, D. W., Gail, M. H., ... & AIDS-Cancer Match Study Group. (1998). Spectrum of AIDS-associated malignant disorders.The Lancet,351(9119), 1833-1839. Chao, C., Silverberg, M. J., Martínez-Maza, O., Chi, M., Abrams, D. I., Haque, R., ... & Said, J. W. (2012). Epstein-Barr virus infection and expression of B-cell oncogenic markers in HIV-related diffuse large B-cell Lymphoma.Clinical Cancer Research, clincanres-3169. Javadi, S., Menias, C. O., Karbasian, N., Shaaban, A., Shah, K., Osman, A., ... & Elsayes,...