Purpose
to identify the effects of chemoradiation therapy on tumour vascularization performing Dynamic Contrast Enhanced Magnetic Resonance (D-CE-MR).
Methods and Materials
we enrolled 18 patients (pts) with locally advanced rectal cancer.
For each patient D-CE-MR was obtained before,
during and after the neoadjuvant treatment by 1.5 T system.
Computer-Aided-Quantitative-Analysis was performed by a system developed in MATLAB for the contranst enhancement analisys.
Basing on MR findings pts were divided in two groups: pts who underwent downstaging (responders),
and pts who did not undergo downstaging (non-responders).
Results
the analysis of numerical values of the Local Peack Intensity (LPI) provided by the software according to the Area Under Curve (AUC),
showed the same statistical significant difference before,
during and after treatment in healthy and pathologic tissue.
An increase of LPI was observed during treatment as compared to the pre-treatment phase,
for healthy and for pathological tissue; on opposite,
LPI in both healthy and pathological tissue showed a post-treatment decrease as compared to pre-treatment and during treatment LPI.
The responders group showed 48% increase...
Conclusion
tumor response more likely occures in pts who report higher LPI values on D-CE-MR analysis during treatment with respect to pre-treatment.
References
Monitoring and predicting response to therapy with 18F-fdg-PET incolorectal cancer: a systematic review; L-F.
de Geus-Oei1,
D.
Vriens; vander Graaf; The Journal of Nuclear Medicine 2009.
Preoperative staging of rectal cancer; Justin MC Young,
Nicholas J Ferris,A Craig Lynch & Alexander G Heriott; Future Oncology 2009.
Role of MRI for staging of rectal cancer; Kartik S Jhaveri and Arifa Sadaf;Expert Reviews 2009.
Imaging as a surveillance tool in rectal cancer; M.
Bellomi,
L.
Travaini;Expert reviews 2010.
Functional Imaging of Colorectal Cancer: Positron Emission Tomography,
Magnetic...
Personal Information
Dr.
Riccardo Del Vescovo MD
Department of Radiology
University Campus Bio-Medico School of Medicine
Via Alvaro del Portillo 200,
00128 Rome
Cell.:+39-338-1111915
e-mail:
[email protected]
