Learningobjectives: 1. To illustrate myriad imaging features of brain and spinal cord seen in association with dengue infection and also provide clinical spectrum of the disease. 2. To understand and correlate its pathophysiology which will further help to make the management strategy better and easier.

EPIDEMIOLOGY, PATHOPHYSIOLOGY AND CLINICAL SPECTRUM: Dengue virus (DENV) infection is one of the most rapidly spreading arboviral infection worldwide. It is a single stranded RNA virus of flavivirus genus and family flaviviridae. It has 4 serotypes and serotypes 2 and 3 are associated with severe disease and neurological involvement. [1, 2, 3] It is transmitted by mosquitoes of the genusAedes, which are widely distributed in subtropical and tropical areas of the world (Figure 1). Patients typically give history of living in or recent travel to...

CASE 1 A 41 years old male presented with fever since 3 days and sudden onset of unconsciousness since 1 day. Clinical examination revealed petechiae all over his body. On MRI, we could see multiple T2 and FLAIR hyperintensities in bilateral cerebral hemispheres and involvement of corpus callosum. Few areas appear hyperintense on T1 and show blooming on gradient (GRE) sequence (Figure 5). His CSF was positive for dengue antibodies. CASE 2 A 30 years old patient presented with fever and chills for 6 days...

Conclusion: Careful attention to history, serological tests and characteristic imaging features can help us diagnose dengue infection with ease and reduce morbidity and mortality associated with it. Radiologist should be aware of its myriad imaging features and some unique clues like hemorrhagic lesions along with knowledge of its pathophysiology so that we can help the society for tackling this upcoming hazard. Dengue should always be considered as a differential diagnosis in hemorrhagic encephalitis and non-hemorrhagic encephalitis as well if not explained by other causes.

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