Chronic obstructive pulmonary disease (COPD) was listed as the third leading cause of death by the World Heath Organizationwith 3.1 million deaths per year. COPD mainly charaterized by irreversible airway obstructions, is largely avoidable and caused by inhaled noxae respectivley particles. Besides clinical criteria, the diagnostic guidelines for COPDare based on spirometric measurements of forced expiratory volume in one second (FEV1) and forced vital capacity (FVC).However, this does not address the pathophysiological complexity of the disease sufficiently. Until now, inspiratory chest computed tomography has been...

Lung function testing Forty-six patients with diagnosed COPD underwent body plethysmography, acquiring the following parameters: vital capacity (VC), forced expiratory volume (FEV1), Tiffeneau index (FEV1%VC), residual volume (RV), total lung capacity (TLC), ratio of residual volume to TLC (RV%TLC) and specific total airway resistance (sRtot). Except forFEV1%VC andRV%TLC, all values are given as percent of predicted, as calculated accoring to ATS/ERS recommendations. CT examination All patients underwent a non-contrast chest CT scan, performed in maximum inspiration and maximum expiration using a 3rd generation dual-source CT...

Regarding inspiratory, expiratory and delta values, we were able to show statistically significant correlations between every qCT parameter and each body plethysmography parameter in either of one of the analysis (inspiration, expiration, delta values). However, there was a strong difference in correlation distribution between inspiratory and the expiratory qCT scan as well as the delta values, as seen exemplified for the MLD in Table 1. As shown in the correlation heatmaps (Fig. 3 & 4), expiratory parameters show improved correlations with spirometric data as compared...

Expiratory qCTand calculated delta values between inspiratory and expiratory scans significantly improve the correlation with lung function parameters. Thus, an additional expiratory qCT may improve image based phenotyping of patients with COPD.

Normal 0 21 false false false DE JA X-NONE The top 10 causes of death [Web page]. World Health Organization; 2014 [updated May 2014; cited 2016 18.09.2016]. Available from: http://www.who.int/mediacentre/factsheets/fs310/en/. Normal 0 21 false false false DE JA X-NONE Buist AS, Vollmer WM, McBurnie MA. Worldwide burden of COPD in high- and low-income countries. Part I. The burden of obstructive lung disease (BOLD) initiative. Int J Tuberc Lung Dis. 2008;12:703-8. Normal 0 21 false false false DE JA X-NONE Vestbo J, Hurd SS, Agusti AG,...