Breast cancer accounts for one in ten of all new cancers diagnosed worldwide every year. The developing countries account for 45% of the global burden, but the incidence is rapidly rising in the developing countries [1, 2]. Breast cancer management involves a multi-pronged approach, including neo-adjuvant chemotherapy (NACT), surgery and radiotherapy. NACT is given pre-operatively to downstage the primary tumor & to eradicate micro metastases. It is used in locally advanced breast cancers to make them operable & in early cancers to enable breast conservation...

Histopathologically proven breast cancer patients scheduled for NACT were enrolled in a prospective study design. Contraindications to chemotherapy including poor performance status, pregnancy, prior administration of chemotherapy, patients unwilling to undergo chemotherapy and previous surgeries/breast implants in ipsilateral breast constituted the exclusion criteria. Written informed consent was obtained from all the patients. The Institute Ethical Committee clearance was obtained prior to the commencement of the study Clinical workup Detailed clinical history was obtained. This included age, sex, menstrual status, relevant family history, significant past history...

*Twenty eight patients with 29 masses (including a female with bilateral breast cancer) were analysed pre and post NACT with B-mode US and SWE. There were 27 females and 1 male havinga mean age of 46.5 +/-11.1 years. All patients presented with breast lump.The demographic characteristics were not statistically significant between the responders and non-responders, although the responder group had more pre-menopausal women than the non-responder group (Table1) Table 1: Demographic profile of patients (comparison of responders and non-responders) : Responders (n=13) Non-responders (n=16) P...

SWE is a promising technique to assess NACT response in breast carcinoma. Early prediction of NACT response using SWE would help tailor the management. The potential non-responders could be identified early in the course of treatment and the regimen or treatment could be altered, thus avoiding unnecessay toxicity of chemotherapaeutic agents. Although no relationship could be found between the baseline tissue elasticity and pathological response, the post-treatment elasticity change even after the 1st cycle of chemotherapy showed correlation with the pathological response and could thus...

Vidyasagar Ramalingam Department of Radiology, All India Institute of Medical Sciences (AIIMS) New Delhi, India [email protected] Smriti Hari Department of Radiology, All India Institute of Medical Sciences (AIIMS) New Delhi, India Shashi Bala Paul Department of Radiology, All India Institute of Medical Sciences (AIIMS) New Delhi, India Sanjay Thulkar Department of Radiology, All India Institute of Medical Sciences (AIIMS) New Delhi, India Surabhi Vyas Department of Radiology, All India Institute of Medical Sciences (AIIMS) New Delhi, India Ajay Gogia Department of Medical Oncology, All India...

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