Aims and objectives
The most frequently diagnosed cancer among women worldwide is breast cancer,
it is also the leader among deaths caused by cancer in women but the mortality rate of breast cancer has reduced in recent years [1].
This progress may be in part due to advancements in imaging modalities which are used in the screening and diagnosis of breast cancer.
When breast cancer diagnosis is established,
further evaluations are required to understand the extent of the disease and determine treatment path(s).
The determination of prognosis is...
Methods and materials
The study was designed as a prospective study of invasive ductal breast cancer patients who had been treated at Ankara Oncology Training and Research Hospital between 2015 and 2016.
Ethical approval was obtained from the local ethics committee.
Additional approval was obtained from the hospital board as our institution is considered as a reference hospital for breast cancer.
The MRI values and dynamic results of patients who had MR indications and had underwent MR imaging which revealed they had BIRADS-4 or BIRADS-5 lesions were recorded....
Results
We included 81 female patients into our study,
mean age was 47.27 ± 12.13.
Sixty-three (77.8%) patients had IDC while 9 (11.1%) patients had ILC.
When we evaluated tumor grades there were 11 (14.9%) patients with Grade 1,
29 (29.2%) patients with Grade 2 and 34 (%45.9) patients with Grade 3 tumor,
while grading for 7 patients were missing.
Forty-five (55.6%) patients had DCIS component while 10 (12.3%) had LCIS component.
Twenty patients had lymphovascular invasion and 4 (4.9%) patients received neoadjuvant chemotherapy.
When we...
Conclusion
We aimed to identify any relationship between dynamic MRI findings (with a focus on washout type curve) and factors that affect prognosis in invasive ductal breast cancers.
Currently; tumor size and type,
histological grade,
lymph node status,
lymphovascular invasion (LVI),
steroid receptor (estrogen and progesterone) and human epidermal growth factor receptor expressions,
and proliferation markers such as Ki-67 are accepted as important prognosis determining/effecting factors.
Contrast-enhanced dynamic MRI is currently an important imaging tool in the evaluation of invasive breast cancer.
The imaging findings can...
Personal information
Hale AYDIN,
MD
Mailing Address: Dr AY Ankara Oncology Research and Training Hospital
Mehmet Akif Ersoy Mah 13.
Cadde No: 56 Yenimahalle Ankara - TURKEY
Phone: 090 312 336 0909 – 4654
Cell Phone: 090 533 312 9808
E-mail:
[email protected]
References
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W.H.,
International Agency For Research on Cancer GLOBOCAN 2012: estimated cancer incidence,
mortality and prevalence worldwide in 2012.
2013.
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S.,
et al.,
Correlation of the apparent diffusion coefficiency values on diffusion-weighted imaging with prognostic factors for breast cancer. The British journal of radiology,
2014.
3- Shen,
J.,
et al.,
Intramammary lymph node metastases are an independent predictor of poor outcome in patients with breast carcinoma. Cancer,
2004.
101(6): p.
1330-7.
4- Kutomi,
G.,
et al.,
Current status of the prognostic molecular...