Learning objectives
To clarify if the dynamic contrast-enhanced MRI quantitative parameter Ve has a role in predicting therapy response or outcome in cancer patients.
Background
Dynamic contrast enhanced MRI (DCE-MRI) permits assessment of the vascular status of tumours and adjacent tissue [1].
The technique not only has the potential to be used at the diagnostic stage to differentiate between tumour types [2],
but it can also be used to assess the relationships between the microvascular function of tumours pre and post therapy [1].
An ROI is drawn over the tumours and several parameters can be derived.
DCE-MRI parameters range from simple semiquantitative data obtained from time-signal intensity plots [3] ranging...
Findings and procedure details
Data sources and search strategy
We performed a primary literature search on MEDLINE for DCE-MRI,
Ve and variations thereof with the following search string:
((((((Dynamic contrast-enhanced MRI[Title]) OR DCE-MRI[Title]) OR Dynamic contrast-enhanced magnetic resonance imaging[Title]) OR Dynamic contrast enhanced MRI[Title]) OR DCE MRI[Title]) OR DCE[Title]) AND ("Ve"[Title/Abstract] OR "V(e)"[Title/Abstract]).
Based upon our inclusion/exclusion criteria 27 out of 314 articles were eligible,
totalling 1128 patients with a variety of primary tumours.
Selection criteria
Results were limited to human studies in English.
Studies were included if they...
Conclusion
Studies were heterogeneous in their methods and results and hence drawing conclusive results is challenging.
The role of the DCE-MRI parameter Ve in predicting response to malignant disease remains in question.
We would advocate further research using standardised methodology in a wider range of tumour types to obtain a more definitive answer.
Personal information
Ashik Amlani
Academic Clinical Fellow,
ST1 Radiology Registrar
Radiology Department
Guy's and St.
Thomas' NHS Foundation Trust
Westminster Bridge Rd,
Lambeth,
London SE1 7EH
[email protected]
References
1 O'Connor JP,
Tofts PS,
Miles KA,
Parkes LM,
Thompson G,
Jackson A.
Dynamic contrast-enhanced imaging techniques: CT and MRI.
Br J Radiol.
2011;84 Spec No 2:S112-20.
2 Jiang J,
Xiao Z,
Tang Z,
Zhong Y,
Qiang J.
Differentiating between benign and malignant sinonasal lesions using dynamic contrast-enhanced MRI and intravoxel incoherent motion.
Eur J Radiol.
2018;98:7-13.
3 Zahra MA,
Hollingsworth KG,
Sala E,
Lomas DJ,
Tan LT.
Dynamic contrast-enhanced MRI as a predictor of tumour response to radiotherapy.
Lancet Oncol.
2007;8(1):63-74.
4 Huang W,...
