18 F PET/CT in assessment of treatment response in osteosarcoma: how could it help

Congress:

ECR 2018

Poster Number:

C-1006

Type:

Scientific Exhibit

Keywords:

Hybrid Imaging, Nuclear medicine, PET-CT, Diagnostic procedure, Cancer

Authors:

I. M. M. Elantably, M. M. A. Rezk, W. R. omar, A. R. zaher, G. R. younes, M. R. zamzam; Cairo/EG

DOI:

10.1594/ecr2018/C-1006

DOI-Link:

https://dx.doi.org/10.1594/ecr2018/C-1006

Fig. 1: response of left knee osteosarcoma after CTH

Fig. 2: response of left knee osteosarcoma after CTH

Fig. 3: response of left knee osteosarcoma after CTH

Fig. 4: response of left knee osteosarcoma after CTH

Aims and objectives

to evaluate the role of F-18 FDG PET/CT in the assessment of neo-adjuvant chemotherapy response after W5 and W10 (before local surgical control) compared to percentage tumor necrosis after surgical excision of the tumor.

Methods and materials

Patients Criteria and Study Design: Prospective study For 46 patients with histologically proven osteosarcoma imaged with PET/CT and MRI before and while they were under treatment at the Children Cancer Hospital, Egypt, (CCHE) during the period from Oct, 2014 to Oct, 2016. The age of patients encountered in the study ranged from five to seventeen years with a median of 13 years, mean of 12.28 +/-0.49 they included 26 males (56.5%) and 20 females (43.5%). Pretreatment Evaluation: Patients underwent conventional evaluation (plain radiography and MRI...

Results

Patient Characteristics Prospective study For 46 patients with histologically proven osteosarcoma who were under treatment and regular follow up at the Children Cancer Hospital, Egypt, (CCHE) during the period from Oct, 2014 to Oct, 2016. The age of patients encountered in the study ranged from five to seventeen years with a median of 13 years, mean of 12.28 +/-0.49. They included 26 males (56.5%) and twenty females (43.5%) (Fig. 12). On the basis of histo-pathology, All patients had high grade osteosarcomas except one patient. Twenty...

Conclusion

· 18F-FDG PET performed after the first cycle of NAC (post week five assessment) is useful to predict a poor histologic response as well as following completion of NAC (post week ten) in patients with osteosarcoma. · PET/CT parameters are capable of predicting histological response with overall sensitivity and specificity higher than MRTV parameters. · According to the PET/CT parameters, SUVmax values had an overall sensitivities and specificities higher than those of tumor liver ratios (TLRs).

Personal information

References

1. Kim SY, Helman LJ. Strategies to Explore New Approaches in the Investigation and Treatment of Osteosarcoma.Cancer Treat Res. 2010. 152:517-528. 1. Bajpai J, Gamnagatti S, Kumar R, et al. Role of MR imaging in osteosarcoma for evaluation and prediction of chemotherapy response: correlation with histological necrosis. Pediatr Radiol. 2011;41:441–450. 1. Im HJ, Kim TS, Park SY, et al. Prediction of tumour necrosis fractions using metabolic and volumetric 18F-FDG PET/CT indices, after one course and at the completion of neoadjuvant chemotherapy, in children and young...