Correlation between BRCA1 and BRCA2 mutation, imaging and histopathological characteristics in patients with breast cancer BRCA-related.

Congress:

ECR 2019

Poster Number:

C-0834

Type:

Scientific Exhibit

Keywords:

Breast, Oncology, MR, Mammography, Ultrasound, Screening, Multidisciplinary cancer care, Neoplasia, Genetic defects

Authors:

S. Paolicelli¹, L. Coi¹, R. Virelli¹, M. Telegrafo², F. mercadante¹, N. Resta¹, M. Moschetta¹; ¹Bari/IT, ²TRIGGIANO/IT

DOI:

10.26044/ecr2019/C-0834

DOI-Link:

https://dx.doi.org/10.26044/ecr2019/C-0834

Fig. 1: Breast cancer in a 34 year old patient with BRCA 1 genetic mutation

Fig. 2: Breast cancer in a 41-year-old patient with BRCA 2 genetic mutation

Fig. 3: Breast cancer in a 51-year-old patient with BRCA 2 genetic mutation

Aims and objectives

BRCA mutation represents a crucial information for breast cancer personalized screening and requires MR evaluation of the breast glands in order to detect early breast cancer. The aim of the study is to evaluate a possible correlation between imaging and histopathological characteristics and BRCA 1 or BRCA 2 genetic mutations in the breast cancer.

Methods and materials

464 patients selected between 2013 and 2017, 97patients were included (94 women, 3 males), between probands and family members, with BRCA 1 (52) and BRCA 2 (45) mutation, affected by breast cancer, undergoing mammography, ultrasound and MRI. MR imaging examinations were performed on a 1.5 TMR device (Achieva®, Philips Medical Systems, Best, The Netherlands) by using a four channel breast coil. MR examination was performed in the second week of menstrual cycle in case of pre-menopausal women. The protocol included a short TI inversion recovery...

Results

Concerning the histological and receptorial pattern, the triple negative subtype was prevalent among BRCA 1 lesions compared to the BRCA 2 related (37.5% vs. 12.5%). At mammography, ultrasound and MRI, the BRCA 1 related lesions tend to present oval morphology and regular edges compared with BRCA 2 lesions (29.1% vs 8%). At the MRI exam, BRCA 2 related lesions presented irregular morphology and margins and inhomogeneous enhancement (88% vs. 67.3%) as compared with BRCA 1. In BRCA 1 mutated patients the percentage of lesions with...

Conclusion

Breast BRCA 1 tumors show more regular morphological featues in the different imaging methods. However, among the BRCA 1 lesions, the triple negative pattern results to be prevalent.

Personal information

Dr Simona Paolicelli Breast Care Unit Department of Radiology University of Bari Medical School Italy [email protected]

References

1.Association of BRCA Mutation Types, Imaging Features, and Pathologic Findings in Patients With Breast Cancer With BRCA1 and BRCA2 Mutations. Ha SM1,Chae EY2,Cha JH2,Kim HH2,Shin HJ2,Choi WJ2.AJR Am J Roentgenol.2017 Oct;209(4):920-928. doi: 10.2214/AJR.16.16957. 2.Breast tumor characteristics ofBRCA1andBRCA2gene mutation carriers on MRI.Veltman J, Mann R, Kok T, et al.Eur Radiol2008; 18:931–938. 3.Magnetic resonance imaging of breast cancer patients with BRCA mutation.Chung SY, Cha JH, Kim HH, et al.J Korean Soc Magn Reson Med2013; 17:207–214. 4.Association betweenBRCAmutation status, pathological findings, and magnetic resonance imaging features in patients...