To show the Tuberous sclerosis complex (TSC) as a multisystemic diseases To illustrate the imaging findings in TSC

Tuberous sclerosis complex is an autosomal dominantneurocutaneousdisorder which morphologically presents with hamartomous changes in brain, kidneys, lungs, skin, retina and the heart. The diagnosis is established based on the clinical and radiological findings. It is a genetic disease, but sporadi cases are more common.Its incidenceranges from one in 6000 to one in 12000, no sex predominance is observed.

Nephrology and Neurology patients with TSC were referred to the imaging department for MRI of the brain and abdomen and CT of the lungs. MRI was performed on a 3T Verio Machine, using 0.1mmol/kg Gadovist contrast medium. CT of the lungs was performed on 64slices Aquillion with iodine contrast medium. Brain MRI included: precontrast sagittal MPR, axial T2 and FLAIR, Diffusion weighted imaging (DWI), DIR (double inversion recovery), SWI (Susceptibility weighted imaging) and postcontrast T1 images. MRI of the abdomen was obtained using: T1 and...

TSC is a disease that affects different organs, thus it needs team work to diagnose this condition. The role of the radiologist is in assessing the changes as imaging diagnosis is often the first diagnostic tool.

Shigeaki Umeoka,Takashi Koyama,Yukio Miki,Mikio Akai,Kazushige Tsutsui,Kaori Togashi Published Online:Nov 1 2008https://doi.org/10.1148/rg.e32 NarayananV. Tuberous sclerosis complex: genetics to pathogenesis.Pediatr Neurol2003;29:404–409.Crossref,Medline,Google Scholar ShepherdCW, Gomez MR, Lie JT, Crowson CS. Causes of death in patients with tuberous sclerosis.Mayo Clin Proc1991;66:792–796.Crossref,Medline,Google Scholar