Metastatic new disease in ovarian cancer: organ location and impact

Congress:

ECR 2019

Poster Number:

C-2951

Type:

Scientific Exhibit

Keywords:

Oncology, Molecular imaging, Computer applications, CT, MR, PET-CT, Computer Applications-Teleradiology, Efficacy studies, Structured reporting, Metastases, Outcomes, Multidisciplinary cancer care

Authors:

M. SHARMA¹, O. Bohnsack², D. Clark², N. Rohra¹; ¹HYDERABAD/IN, ²Berlin/DE

DOI:

10.26044/ecr2019/C-2951

DOI-Link:

https://dx.doi.org/10.26044/ecr2019/C-2951

Fig. 2: "New Lesion" location and percent across all four studies.

Fig. 4: Disagreement percent between 2 readers in confirming unequivocal nature of new...

Fig. 1: Peritoneal/omental metastasis, hallmark of ovarian cancer is often reported...

Fig. 5: Peritoneal metastasis progression seen in two different patients over a period...

Aims and objectives

Metastasis is the leading cause of ovarian cancer (OC) related death with more than 70% of OC patients diagnosed with metastasis with five-year survival rates below 45%. The highest age-adjusted incidence rates are observed in developed parts of the world, including North America and Central and Eastern Europe, with rates generally exceeding 8 per 100,000. Rates are intermediate in South America (5.8 per 100,000), and lowest in Asia and Africa [1]. OC has a unique pattern of metastasis where the hematogenous spread is less common....

Methods and materials

Patient Population: Retrospective study and analysis of four randomized double-blind trials was performed in patients with Ovarian Cancer. Study 1 included placebo controlled patient data with platinum sensitive ovarian cancer. Study 2 included maintenance monotherapy in advanced (FIGO Stage III-IV) ovarian cancer following first line platinum-based chemotherapy. Study 3 focused on patients who are in complete or partial response following platinum-based chemotherapy. Study 4 involved patients with recurrent or persistent low-grade serous carcinomas of the ovary, fallopian tube or primary peritoneum. Data was analyzed from...

Results

Location / Organ of “new lesion” metastasis was recorded for each subject per study across all visits. Understanding the mode of spread and site of metastasis is critical in designing effective treatment therapy. Based on the results from total count, frequency of various organs involved in OC metastasis was evaluated. For all studies combined involving 1491 subjects, total subjects with new metastasis observed in decreasing order for various organs were peritoneum/omentum (527), lymph nodes (415), ascites (303), liver (142), pleural effusion (117), pelvis (99) &...

Conclusion

For the four studies analyzed, Peritoneum/Omentum is the most common site of involvement in OC metastasis in three studies and lymph node is the most common site of OC metastasis in one study. The other most common sites of metastases are ascites, liver, pleural effusion, pelvis and lung. This study confirms peritoneal spread being the most common form for metastasis in OC. It is also observed that the frequency of disagreement between two readers is high for peritoneal and lymph node metastasis making the need...

Personal information

Manish Sharma, MD Vice President, Scientific and Medical Services Patient Technology Solutions, Medical Imaging PAREXEL International 11th Floor, Bldg # 20, Mindspace, Madhapur Hyderabad, India 500081 Phone: +91 40.6604.4826 Email: [email protected]

References

Brett M. Reid, Jennifer B. Permuth, Thomas A. Sellers, Epidemiology of ovarian cancer: a review, Cancer Biol Med 2017, 14(1), February 2017 doi: 10.20892/j.issn.2095-3941.2016.0084. G. Cormio, C. Rossi, A. Cazzolla, L. Resta, G. Loverro, P. Greco, L. Selvaggi, International Journal of Gynecological Cancer, 2003, 13, 125—129. Anirban K. Mitra, Ovarian Cancer Metastasis: A Unique Mechanism of Dissemination, http://dx.doi.org/DOI:10.5772/64700 E.A. Eisenhauer, P. Therasse, J. Bogaerts, L.H. Schwartz, D. Sargent, R. Ford, J. Dancey, S. Arbuck, S. Gwyther, M. Mooney, L. Rubinstein, L. Shankar, L. Dodd, R....