|ECR 2019 / C-2567|
|Using ASL-perfusion to detection of residual glioblastoma tissue after surgical treatment|
As a result of the study all patients were divided into two groups depending on the CBF value.
1st group - 38 patients (67.9%) with a pathological increase in cerebral blood flow on ASL perfusion cards (presumably a tumor – ROI 1), the average CBF was 137.6 ± 35.2 ml/100g/min (minimum - 79.6 ml/100g/min, max - 227.6 ml/100g/min) (Fig.2). In this patients the CBF value of the supposed tumor site was 5-6 times higher than the blood flow in the area of postoperative scars (ROI 2), the average CBF here was 23.6 ± 6.3 ml/100g/min and 6-8 times higher than the CBF of the deep white matter of the brain in the contralateral hemisphere (ROI 3), which was 20.3 ± 4.7 ml/100g/min, (p<0,0001) (Fig. 3).
2nd Group - 18 patients (32.1%) with no areas of pathological CBF elevation on ASL-perfusion maps against the background of postoperative changes, the average level of CBF in the study area (ROI 1 and ROI 2 were similar) was 22.3 ± 5.9 ml/100g/min (minimum - 13.9 ml/100g/min, maximum - 37.1 ml/100g/min). It is almost identical to the white matter of the brain in the contralateral hemisphere (ROI 3), where the average CBF was 19.1 ± 4.4 ml/100g/min (Fig. 4).
The levels of CBF in the areas of postoperative changes in patients from the 1st and 2nd groups were not significantly different, p = 0.52. Also there was no significant differences between groups in CBF levels in the white matter of the brain, p = 0.96.
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