Aims and objectives
The purpose of this study was to evaluate the efficacy of the semi-quantitative and quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in differentiating benign and malignant soft tissue tumours.
Methods and materials
Totally 45 patients with pathologically confirmed soft tissue tumours (15 benign tumours and 30 malignant tumours) underwent DCE-MRI.
The semi-quantitative parameters were as follows: time to peak (TTP),
maximum concentration (MAX Conc.),
area under curve of time-concentration curve (AUC-TC),
and maximum rise slope (MAX Slope).
Quantitative DCE-MRI was analysed with the Extended Tofts–Kety model to obtain the following quantitative parameters: Ktrans,
Kep,
and Ve.
Data were evaluated using the independent t test or Mann–Whitney U test analysis and receiver operating characteristic (ROC) curves.
The following...
Results
In benign tumours,
significant differences existed in MAX Conc.
(p=0.000),
AUC-TC (p=0.000),
MAX Slope (p=0.000),
Ktrans (p=0.000),
Kep (p=0.000) and Ve (p=0.001) between the lesion and control groups.
In malignant tumours,
significant differences existed in TTP (p=0.000),
MAX Conc.
(p=0.000),
AUC-TC (p=0.000),
MAX Slope (p=0.000),
Ktrans (p=0.000),
Kep (p=0.000),
and Ve (p=0.000) between the lesion and the control groups.
There were significant differences in MAX Conc.
(p=0.000),
AUC-TC (p=0.000),
MAX Slope (p=0.000),
Ktrans (p=0.000),
and Kep (p=0.003) between benign soft tissue tumours and malignant soft...
Conclusion
The semi-quantitative and quantitative parameters of DCE-MRI provided the ability to differentiate between benign and malignant soft tissue tumours.
The values of MAX Conc.,
AUC-TC,
MAX Slope,
Ktrans,
and Kep were higher in malignant tumours than in benign tumours.
The use of TTP and Ve values in differentiating between benign and malignant soft tissue tumours needs further study.
Personal information
Dapeng Hao,
MD
Affiliated Hospital of Qingdao University,
Department of Radiology
59 Haier Road,
Laoshan District,
Qingdao,
266071,
China
Phone: 86-0532-82913093
Fax: 86-0532-82913093
e-mail:
[email protected]
References
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Amann G,
Krssak M,
et al (2015) Use of diagnostic dynamic contrast-enhanced (DCE)-MRI for targeting of soft tissue tumour biopsies at 3T: preliminary results.
Eur Radiol 25:2041-2048.
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Matsumine A,
Matsubara T,
et al (2011) The symptom-to-diagnosis delay in soft tissue sarcoma influence the overall survival...