Learning objectives
The aim of this teaching exhibit is: 1. To familiarize radiologist with amyloidosis. 2. To describe a spectrum of imaging features of primary and secundary amyloidosis with pathologic correlation.
Background
Amyloidosis is a collection of disease entities that are characterized by the abnormal extracellular deposition of insoluble amyloid protein.The cause of amyloidosis is unknown. Amyloidosis is seen in a systemic form, although 10-20% of cases can be localized. Manifestations of amyloidosis are enormously variable, which often makes the clinical diagosis difficult. Occasionally, rhe radiologic findings may precede the clinical findings. The imaging findings are non especific and diverse reason why the radiologíst must be familiar with them as well as the patient`s clinical history and...
Imaging findings OR Procedure details
We reviewed radiographic studies of 24 patients, with biopsy-proven or post-mortem confirmed cases, diagnosis of amyloidosis over last 10 years, from database of our institution. We find several radiological appearances: focal form, tumorlike lesion or an infiltrative process and it can involve one organ or in conjunction with other organs. In primary amyloidosis, the most common sites involvements are kidneys and skin. The secondary amyloidosis is most frequent presentation and kidney is the organ most common affected. We presented some of findings imaging spectrum, at...
Conclusions
The imaging findings in amyloidosis are extremely diverse and non especific by it must be considered in the differential diagnosis mainly in patients with chronic inflamatory disease. Biopsy is the best method to do accurate diagnostic.
References
Georgiades CS, Neyman EG, Barish MA, Fishman EK. Amyloidosis: review and CT manifestations. Radiographics. 2004 Mar-Apr;24(2):405-16. Urban BA, Fishman EK, Goldman SM, Scott WW Jr, Jones B, Humphrey RL, Hruban RH. CT evaluation of amyloidosis: spectrum of disease. Radiographics. 1993 Nov;13(6):1295-308. Kala Z, Válek V, Kysela P. Amyloidosis of the small intestine. Eur J Radiol. 2007 Jul;63(1):105-9. Epub 2007 Mar 6. Tada S, Iida M, Matsui T, Fuchigami T, Iwashita A, Yao T, Fujishima M. Amyloidosis of the small intestine: findings on double-contrast radiographs. AJR...