Purpose
Among imaging modalities measuring regional cerebral blood flow (CBF),positron emission tomography (PET) is accepted as the gold standard for measuring CBF. Dynamic perfusion computed tomography (CT) studies are easy to perform and readily available without specialized equipment. However, quantitative studies comparing perfusion CT with PET have been few. We assessed the correlation of CBF values obtained from perfusion CT and PET.
Methods and Materials
Subjects: Eleven patients with various cerebrovascular diseases underwent perfusion CT and PET. Characteristics of the patients and the intervals between these two studies are summarized in Table 1. Informed consent was obtained from each patient before the perfusionCT and PET studies.Perfusion CT protocol: At first, conventional CT images of the whole brain were obtained on a four-channel multi-detector row CT scanner. Second, from this series four contiguous 8 mm sections were selected so that at least one of them would include the level of the...
Results
ResultsAverage CBF values of each ROI obtained from perfusion CT and PET are shown in Table 2. In ROIs drawn on cortical gray matter and caudate nuclei (deep gray matter), average CBF values with perfusion CT and PET were 56.84 and 47.86 ml/100g/min, respectively. In ROIs drawn on whiter matter, average CBF values with perfusion CT and PET were 15.78 and 23.15 ml/100g/min, respectively. Average CT-CBF was 19% higher than those with PET-CBF in gray matter, whereas they were 32% lower in white matter.Figure 2-a,...
Conclusion
Our study has shown a moderate correlation of CBF values between perfusion CT and PET. Despite the various alterations of cerebral blood flow in our patients, perfusion CT studies were validated to be an easy-to-perform imaging technique to assess CBF values.
References
Gillard JH et al. Assessment of quantitative computed tomographic cerebral perfusion imaging with H215O2 positron emission tomography. Neurol Res 2000; 22: 457 464Kudo K et al. Quantitative cerebral blood flow measurement with dynamic perfusion CT using the vascular pixel elimination method: Comparison with H215O2 positron emission tomography. AJNR 2003; 24: 419 426Wintermark M et al. Simultaneous measurement of regional cerebral blood flow by perfusion CT and stable xenon CT: A validation study. AJNR 2001; 22: 905-914Frackowiak RS et al. Quantitative measurement of regional cerebral blood...
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