Left ventricular non-compaction cardiomyopathy (LV NC CMP) is a rare condition characterised by numerous excessively prominent left ventricular trabeculation and deep intertrabecular recesses communicating with the ventricular cavity and severely altering myocardial structure [1–4]. It is supposed that LV NC CMP can be caused by arrest of normal embryogenesis of the endocardium and myocardium. It is known that LV NC CMP can be associated with other congenital cardiac defects, but it is also seen in the absence of other cardiac anomalies. During early embryonic development,...

12 patients with LV NC CMP (mean age 39±14; m/f=5/7) were selected from a group of 54 patients with heart failure (HF) or severe arrhythmias of unknown origin referred to 1.5T CMR in 2012-2014. Cardiac MRI (CMRI) was performed with 1.5T-scanner using standard cardiac protocol for assessment of systolic function and viability. Image analysis included calculation of ratio between compacted and non-compacted LV myocardial mass (MM index), measurements of LV volumes, myocardial mass and ejection fraction (EF). Trabeculation index was measured as the ratio between...

In the studied group of patients with LV NC CMP incidence of HF was 83%, rhythm disturbances - 60%. LV was dilated (mean end-diastolic size was 66,3±8,5mm, LV EDV index 133,0±81,3ml/m2), its global contractile function was severely decreased (mean EF=31±14%). NC myocardium was located in the apical and/or mid-ventricular segments of the LV. The mean number of segments with NC (NSNC) per patient was 6±2 and the mean trabeculation index was 4,0±1,5. Significant correlations between LV EDV index and NC LV MM, MM index were...

LV NC CMP should be considered as one of the reasons of HF and significant rhythm disturbances in patients without obvious ethiology of these pathologies. Quantitative analysis of LV geometry in NC CMP patients indicates that the severity of NC may be responsible for LV remodeling in this group of patients.

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