Purpose
Calcification of the coronary arteries is a quite common characteristic finding at chest CT and is a recognized marker of coronary atherosclerosis. The number of chest CTs is growing annually including due to lung cancer screening. A lot of patients who performed chest CT examinations are eligible for calcium score screening. The purpose of this study was to compare the correlations between the gated and non-gated coronary artery calcium score (CACS) values obtained with standard and with low-dose chest CT. The difference in patients' radiation...
Methods and Materials
The study included 425 patients who for the period of November 2017 and June 2018 underwent non-gated chest CT and gated calcium scoring CT. Patients with a history of coronary revascularization or with pacemakers were excluded from the study. ECG-gated cardiac CT for CACS was performed with every eligible patient. CACS was calculated using conventional methods/scores (Agatston, Volume, Mass). Differences and correlations between gated and non-gated CACS values as well as correlation coefficients of standard-dose and low-dose CT groups were evaluated. Statistical analysis was performed...
Results
The study comprised 398 patients. The standard CT protocol was used in 202 cases, and the low-dose one in 196 cases. The value of CACS=0 was found in 109 patients (27%). The mean Agatston values of CACS were 395 ± 583 for gated CACS and 384 ± 602 for non-gated CACS (p=0.41). The correlation between CACS obtained with gated and non-gated CT was high even when "zero" values of CACS were excluded (Agatston: r = 0.975; Volume: r = 0.977; Mass: r = 0.976) (Fig....
Conclusion
The study shows that the calcium score obtained from non-gated standard-dose or low-dose chest CTs is comparable to gated calcium score with a high advantage in low-dose CT in terms of patients radiation dose. These results could be used for combined screening of lung cancer and coronary atherosclerosis.
References
Agatston AS, Janowitz WR, Hildner FJ, et al. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15:827–32.
Kim KP, Einstein AJ, Berrington de González A. Coronary artery calcification screening: estimated radiation dose and cancer risk. Arch Intern Med 2009;169(13):1188–1194.
Hecht HS. Coronary artery calcium scanning: past, present and future. J Am Coll Cardiol Img. 2015;8:579-596.
Xie X., Zhao Y., de Bock G.H., et al. Validation and Prognosis of Coronary Artery Calcium Scoring in Nontriggered Thoracic Computed Tomography. Circ Cardiovasc Imaging....