FT - CMR derived strain ratios provide incremental value in the diagnosis of acute and chronic heart conditions with increased myocardial mass

Congress:

ESCR 2019

Poster Number:

P-0037

Type:

Poster Abstract

Keywords:

Inflammation, Hypertension, Diagnostic procedure, Computer Applications-General, MR, Cardiac

Authors:

M. C. Halfmann, S. Benz, C. Düber, K.-F. Kreitner, T. Emrich; Mainz/DE

DOI:

DOI-Link:

https://dx.doi.org/

Fig. 1: Formula used to calculate ratio strains (rStrain)

Fig. 2: Boxplots representing a) mean absolute values for strain in healthy volunteers...

Fig. 3: HV vs AM: Receiver operator characteristic curves and their respective areas...

Fig. 4: HV vs HHD: Receiver operator characteristic curves and their respective areas...

Purpose

Hypertensive heart disease (HHD) and acute myocarditis (AM) can both present with increased myocardial mass despite different pathophysiology (1, 2). The differentiationbetween them remains difficult. The accompanying distinct patterns of altered myocardial deformation however can be investigated using feature tracking (FT)-CMRstrain. Hence, the aim was to evaluate whether new strain ratios including the myocardial mass per body surface area (MyoMass/BSA) yield additional value in thedifferentiation between both diseases and healthy volunteers.

Methods and Materials

HHD patients (n = 28) andAM patients (n = 43)referred to our department between 09/2014 and 09/2017underwent CMR at 3 T (Magentom Prisma®and Skyra®, Siemens Healthineers).Acarefully selected group of 61 healthy volunteers (HV) served as normal controls. Subsequent FT-strain analysis was performedusing dedicated software (cvi42 circle®) and strain values were evaluated for gender and age specific differences.Subsequently, gender-neutral strain parameters (gStrain) were calculated and then indexed to the MyoMass/BSA leading to ratio Strains (rStrain) (Fig. 1). These were then evaluated for theirdiscriminatory accuracy compared to...

Results

There werestatistically significant (all p

Conclusion

Gender differnces Although there is no widespread consensus on gender-based differences in natural strains yet, the reported findings mostly corroborate what previous studies have suggested(3, 4).As a result of the gender-differences, the overall slightly better performance of the non-adjusted strainsagainst the gStrains in this study can be explained by the elimination of bias after the adjustments. Differences between AM and HHD Each disease showed its own characteristic pattern of altered myocardial deformation. Therefore, each disease had a different strain parameter which illustrated the changes best...

Personal Information

http://www.unimedizin-mainz.de/radiologie/startseite.html

References

Janardhanan R, Kramer CM. Imaging in hypertensive heart disease. Expert Rev Cardiovasc Ther. 2011;9(2):199-209. Zagrosek A, Wassmuth R, Abdel-Aty H, Rudolph A, Dietz R, Schulz-Menger J. Relation between myocardial edema and myocardial mass during the acute and convalescent phase of myocarditis--a CMR study. J Cardiovasc Magn Reson. 2008;10:19. Augustine D, Lewandowski AJ, Lazdam M, Rai A, Francis J, Myerson S, et al. Global and regional left ventricular myocardial deformation measures by magnetic resonance feature tracking in healthy volunteers: comparison with tagging and relevance of gender....