Extracellular Volume Analysis with Cardiac Magnetic Resonance In Patients With Scleroderma

Congress:

ESCR 2019

Poster Number:

P-0056

Type:

Poster Abstract

Keywords:

Inflammation, Connective tissue disorders, Arthritides, Segmentation, Sclerosis, Imaging sequences, MR-Functional imaging, MR-Angiography, MR, Respiratory system, Cardiovascular system, Cardiac

Authors:

G. Lastella¹, C. B. Monti¹, F. D’angelo², A. Ruffino², P. M. Cannao'², F. Sardanelli², F. Secchi²; ¹Milano/IT, ²Milan/IT

DOI:

DOI-Link:

https://dx.doi.org/

Fig. 5: Higher ECV in Sclerodermia patients, compared with healthy subjects

Fig. 1: T1 maps, short axis - ECV evaluation in septum and lateral wall

Fig. 2: T1 maps, long axis - ECV evaluation in anterior and posterior walls

Purpose

To evaluate myocardial extracellular volume (ECV) in patients with scleroderma and the correlations with patient variables.

Methods and Materials

Consecutive patients with scleroderma underwent cardiac magnetic resonance, including cine sequences, and sequences for the evaluation of T1 values and T1 mapping both before and after contrast injection (0,1 mmol/kg of Gadibutrolo). Left ventricular (LV) volumes and function were calculated segmenting cine sequences, both non- and indexed to body surface area. Overall myocardial ECV was then obtained by placing regions of interest both in pre- and post-contrast T1 maps at the septum, anterior wall, lateral wall and posterior wall of the myocardium in short- and...

Results

20 scleroderma patients with a median age of 63 years (IQR 51−67 years), of whom 3 were males (15%) were enrolled. Scleroderma patients had a higher global ECV (33.9%, IQR 35.9−39.2%), when compared to healthy subject reference values (25.6%, normality interval of 19.6−31.6%). Patients had a median LV end-diastolic indexed volume(EDLVi) of 67 ml/m2(IQR 56−78 ml/m2), end-systolic indexed volume (ESLVi) of 21 ml/m2(IQR 17−26 ml/m2), stroke volume (SV) of 72 ml (IQR 56−85 ml), ejection fraction (EF) of 69% (IQR 64−72%), and mass index of...

Conclusion

ECV is increased in scleroderma patients despite the normal LV function and it correlated with the presence of dyspnoea. ECV in scleroderma patients may reflect a diffuse myocardial fibrosis and should be helpful in the detection of early myocardial involvement in these patients.

Personal Information

GiuliaLastella, MD Postgraduation School in Radiodiagnostics Università degli Studi di Milano,Via Festa del Perdono 7, 20122 Milan, Italy Cardiovascular CT/MR Imaging atRadiology Unit, Research Unit Policlinico San Donato, Via Morandi 30, 20097San Donato Milanese,Ita