ECR 2010 / C-0418
Sensitivity and specificity of breast sonoelasticity imaging utilizing color elastography and strain ratio measurements
Keywords:
Breast, Ultrasound
Authors:
T. R. Kumm, J. R. Grajo, A. Chau, T. Tucker, M. Szabunio; Tampa, FL/US
DOI:
10.1594/ecr2010/C-0418
Results
- A total of 285 lesions were evaluated. Of these lesions, 208 were benign and 77 were malignant. Atypia was included as a positive biopsy result.
| Sensitivity | Specificity | PPV | NPV | Accuracy |
ES | 0.57 | 0.74 | 0.47 | 0.82 | 0.77 |
SR | 0.75 | 0.76 | 0.55 | 0.91 | 0.80 |
Diagnostic Performance
- Elastography Scores (ES) were plotted (Fig 1) to demonstrate the frequency of ES negative lesions (0, 1, 2) and ES positive lesions (3, 4, 5). An ES score of 2 was the most frequent ES negative score, while a score of 4 was most common for ES positive scores.
- Strain ratios (SR) were also analyzed among biopsy-proven benign and malignant lesions to determine the mean and range of scores (Fig 2 and 3). The mean SR of the 208 benign lesions was 5.49 with a range of 0.82 to 114.2. The mean strain ratio of the 77 malignant lesions was 20.17 with a range of 1.01 to 107.3.
- Of particular interest in this study was the effect of combining both the ES and SR of breast lesions to reduce the number of false negatives obtained by use of one method alone. We found 16 lesions with false negative result via one method, showed true positive test result using the complementary method (Fig 4).