POSTER SECTIONS Coverpage Learning objectives Background Imaging findings OR Procedure details Conclusion Personal Information References

ECR 2010 / C-1962

Sonography of hepatocellular carcinoma after transarterial chemoembolisation with drug-eluting beads: Emphasis on imaging with echo-enhancer

Congress:

ECR 2010

Poster Number:

C-1962

Type:

Educational Exhibit

Keywords:

Interventional non-vascular, Interventional vascular, Oncology

Authors:

H. Moschouris¹, M. G. Papadaki¹, A. Protopappas¹, I. Kornezos¹, G. Mastorakis¹, K. Malagari², D. Matsaidonis¹; ¹Piraeus/GR, ²Athens/GR

DOI:

10.1594/ecr2010/C-1962

DOI-Link:

https://dx.doi.org/10.1594/ecr2010/C-1962

References

1. Llovet JM, Fuster J, Bruix J; Barcelona-Clínic Liver Cancer Group (2004). The Barcelona approach: diagnosis, staging, and treatment of hepatocellular carcinoma. Liver Transpl.; 10:115-120.

2 . Yamada R, Sato M, Kawabata M, Nakatsuka H, Nakamura K, Takashima S. (1983) Hepatic artery embolization in 120 patients with unresectable hepatoma. Radiology; 148:397-401

3. Ueno K, Miyazono N, Inoue H, Nishida H, Kanetsuki I, Nakajo M.(2000) Transcatheter arterial chemoembolization therapy using iodized oil for patients with unresectable hepatocellular carcinoma: evaluation of three kinds of regimens and analysis of prognostic factors. Cancer; 88:1574-1581

4 . Nakamura H, Hashimoto T, Oi H, Sawada S.(1989) Trancatheter oily chemoembolisation of hepatocellular carcinoma. Radiology; 170:783-786

5 . Marelli L, Stigliano R, Triantos C, et al.(2007) Transarterial therapy for hepatocellular carcinoma: which technique is more effective? A systematic review of cohort and randomized studies. Cardiovasc Intervent Radiol; 30:6-25.

6. Lewis AL, Gonzalez MV, Leppard SW, Brown JE, Stratford PW.(2007) Doxorubicin eluting beads – 1: Effects of drug loading on bead characteristics and drug distribution. J Mater Sci Mater Med.; 18:1691–1699

7. Varela M, Real MI, Burrel M, et al.(2007) Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics. J Hepatol.; 46:474-481.

8. Hong K, Khwaja A, Liapi E, Torbenson MS, Georgiades CS, Geschwind JF.(2006) New intra-arterial drug delivery system for the treatment of liver cancer: preclinical assessment in a rabbit model of liver cancer. Clin Cancer Res.; 12:2563-2567.

9. Malagari K, Alexopoulou E, Chatzimichail K et al. (2008) Transcatheter chemoembolization in the treatment of HCC in patients not eligible for curative treatments: midterm results of doxorubicin-loaded DC bead. Abdom Imaging 33:512-519

10. Malagari K, Chatzimichael K, Alexopoulou E, et al. (2008) Transarterial chemoembolization of unresectable hepatocellular carcinoma with drug eluting beads: results of an open-label study of 62 patients. Cardiovasc Intervent Radiol 31:269-280.

11. Aliberti C, Benea G, Tilli M, et al.(2008) Chemoembolization (TACE) of unresectable intrahepatic cholangiocarcinoma with slow-release doxorubicin-eluting beads: preliminary results. Cardiovasc Intervent Radiol. 31(5):883-8.

12. Aliberti C, Tilli M, Benea G, Fiorentini G.(2006) Trans-arterial chemoembolization (TACE) of liver metastases from colorectal cancer using irinotecan-eluting beads: preliminary results. Anticancer Res;26(5B):3793-5.

13. Bruix J, Sherman M, Llovet JM, et al. (2001) Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol. 35:421-430.

14. Ebied OM, Federle MP, Carr BI, et al (2003) Evaluation of responses to chemoembolization in patients with unresectable hepatocellular carcinoma. Cancer ; 97:1042-1050.

15. Kloeckner R, Otto G, Biesterfeld S, et al. (2009) MDCT Versus MRI Assessment of Tumor Response After Transarterial Chemoembolization for the Treatment of Hepatocellular Carcinoma. Cardiovasc Intervent Radiol. [Epub ahead of print]

16. Numata K, Tanaka K, Kiba T, et al.(2001) Using contrast-enhanced sonography to assess the effectiveness of transcatheter arterial embolization for hepatocellular carcinoma. AJR 176:1199-1205.

17. Ding H, Kudo M, Onda H, et al. (2001) Evaluation of posttreatment response of hepatocellular carcinoma with contrast-enhanced coded phase-inversion harmonic US: comparison with dynamic CT. Radiology 221:721-30.

18. Minami Y, Kudo M, Kawasaki T, et al. (2003) Transcatheter arterial chemoembolization of hepatocellular carcinoma: usefulness of coded phase-inversion harmonic sonography. AJR 180:703-708.

19. Morimoto M, Shirato K, Sugimori K, et al. (2003) Contrast-enhanced harmonic gray-scale sonographic-histologic correlation of the therapeutic effects of transcatheter arterial chemoembolization in patients with hepatocellular carcinoma. AJR 181:65-69.

20. Pompili M, Riccardi L, Covino M, et al. (2005) Contrast-enhanced gray-scale harmonic ultrasound in the efficacy assessment of ablation treatments for hepatocellular carcinoma. Liver Int 25:954-961

21. Kim HJ, Kim TK, Kim PN, et al. (2006) Assessment of the therapeutic response of hepatocellular carcinoma treated with transcatheter arterial chemoembolization: comparison of contrast-enhanced sonography and 3-phase computed tomography. J Ultrasound Med. 25:477-486.

22. Kono Y, Lucidarme O, Choi SH, et al. (2007) Contrast-enhanced ultrasound as a predictor of treatment efficacy within 2 weeks after transarterial chemoembolization of hepatocellular carcinoma. J Vasc Interv Radiol 18:57-65.

23. Xia Y, Kudo M, Minami Y, et al. (2008) Response evaluation of transcatheter arterial chemoembolization in hepatocellular carcinomas: the usefulness of sonazoid-enhanced harmonic sonography. Oncology 75:99-105.

24. Ohishi H, Uchida H, Kurosaki Y, et al.(1983) Evaluation by ultrasonography of arterial embolization therapy for hepatocellular carcinoma. Cardiovasc Intervent Radiol.;6(2):104-8.

25. Onodera H, Oikawa M, Abe M, Chida N, Goto Y.(1985) Serial changes in sonographic appearance after transcatheter hepatic arterial embolization. J Ultrasound Med.;4(8):401-4.

26. Tanaka K, Inoue S, Numata K, Takamura Y, Takebayashi S, Ohaki Y, Misugi K. Color Doppler sonography of hepatocellular carcinoma before and after treatment by transcatheter arterial embolization. AJR 1992; 158:541-546.

27.Hosoki T, Yosioka Y, Matsubara T, Minamitani K, Higashi M, Ohtani M, Choi S, Mitomo M, Tono T. Power Doppler sonography of hepatocellular carcinoma treated by transcatheter arterial chemoembolization. Assessment of the therapeutic effect. Acta Radiol. 1999; 40:639-643.

28. Cioni D, Lencioni R, Bartolozzi C.(2000) Therapeutic effect of transcatheter arterial chemoembolization on hepatocellular carcinoma: evaluation with contrast-enhanced harmonic power Doppler ultrasound. Eur Radiol.;10:1570-1575.

29. Ikeya S, Takayasu K, Muramatsu Y, Moriyama N, Hasegawa H, Hirohashi S.(1990) Evaluation of the efficacy of oil chemoembolization for hepatocellular carcinoma by computed tomography:a proposal for altering the criteria to indicate the efficacy. Jpn J Cancer Clin; 36:985–992

30. Takayasu K, Arii S, Matsuo N, et al (2000). Comparison of CT findings with resected specimens after chemoembolization with iodized oil for hepatocellular carcinoma. AJR; 175:699-704.

31. Therasse P, Arbuck SG, Eisenhauer EA, et al. (2000) New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92:205–216

32. Nakashima Y, Nakashima O, Hsia CC, Kojiro M, Tabor E.(1999) Vascularization of small hepatocellular carcinomas: correlation with differentiation. Liver ; 19:12-18.

33. Moschouris H, Malagari K, Papadaki MG, Kornezos I, Matsaidonis D.(2010). Contrast-Enhanced Ultrasonography of Hepatocellular Carcinoma After Chemoembolisation Using Drug-Eluting Beads: A Pilot Study Focused on Sustained Tumor Necrosis. Cardiovasc Intervent Radiol. [Epub ahead of print]

34 . Kim SK, Lim HK, Kim et al.(2003) Hepatocellular carcinoma treated with radio-frequency ablation: spectrum of imaging findings. RadioGraphics; 23:107-121

35. Liu R, Wang JH, Zhou KR, et al.(2005) A comparative study of MRI manifestations and pathological changes in hepatocellular carcinoma treated by transcatheter arterial chemoembolization with lipiodol. Zhonghua Gan Zang Bing Za Zhi.;13:754-758.

36. Guan YS, Sun L, Zhou XP, Li X, Zheng XH.(2004) Hepatocellular carcinoma treated with interventional procedures: CT and MRI follow-up. World J Gastroenterol.; 10:3543-3548.

37. Hwang SH, Yu JS, Chung J, Chung JJ, Kim JH, Kim KW. (2008) Transient hepatic attenuation difference (THAD) following transcatheter arterial chemoembolization for hepatic malignancy: changes on serial CT examinations. Eur Radiol.; 18:1596-1603.

38. Takayasu K, Moriyama N, Muramatsu Y, et al (1985) Gallbladder infarction after hepatic artery embolization.AJR; 144:135-138.

39. Kobayashi 5, Nakamura Y, Terada T, Matsui O (1993) Postmortem survey of bile duct necrosis and biloma in hepatocellular carcinoma after transcatheter arterial chemoembolization therapy: relevance to microvascular damages of peribiliary capillary plexus. Am J Gastroenterol; 88:1410-1415.

40. Sakamoto I, Aso N, Nagaoki K, et al. (1998) Complications associated with transcatheter arterial embolization for hepatic tumors. Radiographics;18(3):605-19.

41. Chung JW, Park JH, Han JK, et al.(1996) Hepatic tumors: predisposing factors for complications of transcatheter oily chemoembolization. Radiology; 198:33-40.

42. Miyayama S, Matsui O, Taki K, et al (2006) Extrahepatic blood supply to hepatocellular carcinoma: angiographic demonstration and transcatheter arterial chemoembolization. Cardiovasc Intervent Radiol.;29(1):39-48.