This poster was previously presented in Spanish at the 2012 Congreso Nacional SERAM (Granada)
Keywords:
Endocrine disorders, Safety, Diagnostic procedure, Contrast agent-intravenous, CT, Kidney, Contrast agents
Authors:
S. Solanas Alava1, R. M. Cozcolluela Cabrejas2, J. Salceda Artola3, N. Yanguas Barea2, R. Bermejo Garcés2, L. A. Sanz Salanova3; 1Tudela Navarra/ES, 2Tudela/ES, 3Tudela (Navarra)/ES
DOI:
10.1594/ecr2013/C-0823
Results
Most of the patients are elderly,
but there are also young patients (outliers on the left),
so that the age curve does not follow a normal distribution.
The mean age of patients was 69 years (Table 1).
In tables in sex distribution,
there is a significant difference,
with more men in the study (Table 2).
In 92% of the cases studied the interval between administration of IV contrast and test performance of renal function was maximum 72h (Table 3).
Ultimately there are not significant differences if the patients were analyzed in terms of age or sex distributions,
or according to the days elapsed between the enhancement CT and the analytical study of renal function.
Concerning values of creatinine (Table 4),
there is no significant difference between creatinine values at baseline and end of study,
or the values before and after contrast medium administration.
No changes in creatinine values in patients with normal baseline renal function.
Therefore,
the data resulting from the study showed that it cannot be said that there was a deterioration of renal function following administration of intravenous iodinated contrast,
at least in patients taking metformin and whose renal function was normal before the scan.
However,
this study did not detect exceptional cases; we identified six patients with elevation of creatinine level after iodinated administration: one case got to 2 mg/dL and four cases above 1.5 mg/dL.
Therefore it is necessary to expand the sample and analyze these factors in more patients to determine causal factors.
Although our results are preliminary,
we can say that given the severity of a possible adverse reaction,
such as lactic acidosis,
and although cases of elevated creatinine are isolated but dangerous,
justified the temporary removal of metformin with medical control when iodinated contrast exam will be performed.