Keywords:
Pathology, Outcomes, Biopsy, Ultrasound, Ultrasound physics, Thyroid / Parathyroids
Authors:
S. H. Jeong1, H. Hyun Sook2, E.-H. Lee2; 1Asan Medical Center/KR, 2Soonchunhyang University Hospital/KR
DOI:
10.1594/ecr2013/C-0842
Results
The malignancy rate of initially AUS/FLUS nodules was 55.2% (91/165).
The malignancy rates were 0% in groups 1(0/2),
2(0/3),
4(0/3),
7 (0/3) and 8(0/1),
76.5% (13/17) in group 3,
83.1% (59/71) in group 5,
and 29.2% (19/65) in group 9.
The malignancy rate of nodules with suspicious US features was 79.3% (73/92) and the malignancy rate with intermediate US features was 24.7% (18/73).
Among suspicious US features,
nodules with a taller-than-wide shape showed a significantly higher odds ratio compared to those with an oval shape (odds ratio: 11.25; P = 0.00); however,
round and irregularly shaped nodules did not show significantly higher odds ratios (P = 0.13 and 0.11,
respectively).
An ill-defined margin showed a higher odds compared with an oval shape however,
the P-value was 0.06,
which was not statistically significant.
(odds ratio: 1.83).
microlobulated and spiculated nodules showed no significant difference (P = 0.06 and 0.24,
respectively).
Micro- and macrocalcifications showed significantly higher odds compared with no calcification (odds ratios: 5.17 and 12.22,
respectively; P = 0.00,
respectively),
whereas rim calcifications showed no significant difference (P = 0.91).
Marked hypoechogenicity showed a higher odds ratio compared with hyperechogenicity(odds ratio: 6.40); however,
the P-value was 0.17,
which was not statistically significant.
In the present study,
the presence of micro- and macrocalcifications and a taller-than-wide shape showed higher odds ratios and were significantly correlated with malignancy.
The likelihood of malignant thyroid nodule in BRAF600E-positive nodules was 97.5% (39/40) and 39.7% (25/63) in BRAFV600E negative nodules (P < 0.05).