Keywords:
Cancer, Experimental investigations, MR-Diffusion/Perfusion, MR, Pelvis, Genital / Reproductive system male
Authors:
C. Cecchelli, C. Gaudiano, F. Busato, R. Golfieri; Bologna (BO)/IT
DOI:
10.1594/ecr2013/C-1295
Results
On the basis of biopsy and/or clinical follow-up,
11/22 patients had a local recurrence; in this group mean (± SD) PSA level was 1,64 ± 1,25 ng/ml,
at the time of MRI.
11/11 patients (100%) had positive MRI findings (Figure 2),
in detail: T2-weighted images showed an hyperintense nodule in 8/11 (72.7%); DWI showed an hyperintense nodule in 9/11 (82%) patients,; DCE-MRI showed type 1 T/I curve in 3 (27%),
type 2 in 7 (64%) and type 3 in 1 (9%).
In patients without local recurrence,
mean PSA level was 1 ± 1,19 ng/ml.
MRI was negative in 9/11 (82%) patients (Figures 3,
4),
in detail: T2-weighted images showed hypointense tissue in 7/11 (63.6%); DWI showed hypointense tissue in 8/11 (89%) and DCE-MRI showed type 2 T/I curves in 3/11 (27%) and type 3 in 8/11 (72.7%).
ROC analysis showed for each sequence the following values of sensitivity,
specificity,
NPV and PPV (Figure 5): 72.7%,
63.6 %,
70%,
66.7% for T2 sequence; 81.8%,
72.7%,
80%,
75% for DWI sequence; 90.9%,
66.6%,
87.5%,
71.4% for DCE-MRI sequence.
Combined evaluation of DWI and DCE-MRI results showed the following values for the same parameters: 100%,
81.8%,
100%,
84.6%.