Keywords:
Cardiac, MR, Diagnostic procedure, Ischaemia / Infarction
Authors:
C. Tudisca1, G. Aquaro2, E. Oddo3, E. Grassedonio3, M. Lombardi2, M. Midiri3; 1Palermo, PA/IT, 2Pisa/IT, 3Palermo/IT
DOI:
10.1594/ecr2013/C-1573
Methods and Materials
We enrolled 300 patients (67±6 years; 220 male) with the following inclusion criteria:
- no hystory of CAD;
- asymptomatic for angor;
- NYHA class I-II;
- no hystory of cardiac ospedalization;
- new diagnosed LV dysfunction (LV ejection fraction <45%) by ambulatory echocardiographic evaluation.
All the patients performed a CMR examination.
CMR examination was performed with a 1.5T scanner (Signa Excite,
GE).
Protocol included: LV volumes,
mass,
ejection fraction and wall motion using with a conventional approach (acquisition of 3 long axis views and 13-15 cine SSFP short axis views from mitral plane to apex).
DE images were acquired in the same long axis and short axis planes 10 minutes after contrast media (Gd-DTPA 0.2 mmol/Kg) injection using a T1 weighted IR GRE pulse technique with an inversion time optimized to null normal myocardium.
Expert observators evaluated DE images of each patient giving one of the following report:
- post-ischemic pattern,
- non-ischemic pattern,
- absence of enhancement.
Quantitative coronary angiography (the gold standard to predict CAD in LV disfunction), was performed in all the patients after CMR study and CAD was diagnosed when a stenosis ≥50% was detected.
Sensitivity and Specificity of DE-CMR to predict CAD as leading cause of disfunction was evaluated.