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Keywords:
Tissue characterisation, Cirrhosis, Cancer, Experimental investigations, Equipment, Diagnostic procedure, Ultrasound, Experimental, Elastography, Ultrasound physics, Oncology
Authors:
H. E. Ting, C. H. Yeong, B. J. J. Abdullah, K. H. Ng; Kuala Lumpur/MY
DOI:
10.1594/ecr2014/C-1915
Conclusion
The main objective of this study,
which was to investigate tissue elasticity measurement using SWE has been achieved.
An elasticity calibration curve had been constructed to give the reference elasticity values based on the amount of gelatine added.
The calibration curve gave a linear relationship between the elasticity and the mass of gelatine and both the variables were proven to be strongly corelated.
A homogenous phantom that simulates lesions of varying sizes,
stiffness and depth had been constructed to investigate the factors affecting the elasticity.
This study showed that masses of varying sizes had no significant effect on the elasticity values given by the SWE.
However,
depth of the masses does not have conclusive influence on the elasticity measured,
due to lack of data.
Cylindrical and spherical masses had also been incorporated in the phantom to explore the effect of shape on the SWE measurement.
The paired T-test showed that there was no significant difference between elasticity of cylindrical and spherical masses.
The elasticity of the spherical masses had been measured by SWE and the gold standard and then compared.
It was observed that the elasticity measured by SWE is always greater than the elasticity measured by the gold standard.
A paired sample t-test had been performed and results showed that there was a significant difference between the elasticity values given by the SWE and the gold standard.
Thus,
it can be concluded that the elasticity measurement by SWE was an overestimation of the actual elasticity by an unknown factor which needs further investigation.